Objective:To explore the effect of manual making combined physical exercise on rehabilitation and sleep in patients with mental disorders.Methods:A total of 102 patients with mental disorders admitted to Quanzhou Third Hospital in Fujian Prov-ince during the stable period from January 2023 to December 2023 were selected as research objects,and were divided into control group and observation group according to random number table method,with 51 cases in each group.The control group received conventional treatment intervention,and the observation group carried out hand-made combined physical exercise intervention on this basis.The Positive and negative Symptom Scale(PANSS)was used to compare the changes of mental symptoms before and af-ter the intervention,the rehabilitation efficacy Rating Scale for inpatients with mental illness(IPROS)was used to compare the re-habilitation efficacy of the two groups before and after the intervention,and the Pittsburgh Sleep Quality Index(PSQI)was used to compare the changes of sleep quality of the two groups before and after the intervention.Results:Intervention nursing,PANSS scores in 2 groups were decreased,and observation group was significantly lower than control group,the difference between 2 groups was statistically significant(P<0.05);after the intervention,the scores of Rehabilitation Efficacy Rating Scale(IPROS)and PSQI in the observation group were significantly lower than those in the control group,with statistical significance between the two groups(P<0.05).Conclusion:In patients with mental disorders,handicraft combined physical exercise can obviously relieve mental symptoms,improve the rehabilitation effect and improve the sleep quality of patients.