Objective:To analyze the effect of modified position management in operating room on the risk of pressure ulcer and postoperative sleep quality in patients undergoing long-term lateral lying surgery.Methods:From January 2023 to April 2024,60 patients in Xinglin Branch of the First Affiliated Hospital of Xiamen University were divided into two groups by random number method,of which 30 received routine care as the control group and 30 received improved care in the operating room as the obser-vation group.Comparing patient pressure ulcers,comfort performance,and sleep quality.Results:The incidence of pressure ulcer at different time points after operation in observation group was lower than that in control group,the recovery time of spontaneous breathing and anesthesia was shorter,and the scores of GCQ and Richards-Campbell Sleep Scale were higher than those of the control group(P<0.05).Conclusion:Under the modified position management in operating room,the risk of pressure ulcer can be effectively controlled,which can improve the comfort of operation and has a reliable performance in strengthening the sleep quality of patients.