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不同参数电针对内源性阿片肽系统调节的量效关系

Dose-effect relationship between electroacupuncture with different parameters and the regulation of endogenous opioid peptide system

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Endogenous opioid peptides(EOP)are the neurochemical basis of the anesthetic and analgesic effects of acupuncture,and the quantity of acupuncture stimulus can be controlled accurately by using elec-troacupuncture(EA).The present study explores the dose-effect relationship between EA with different parameters and the regulation of EOP system.In this paper,the intervention effects of EA on EOP system were specially discussed in terms of the single factor and the different combinations of the frequency,waveform and current intensity.This study shows that EOP system presents a frequency-response speci-ficity.The low frequency of EA promotes the release of enkephalin,β-endorphin and endomorphin,the high one activates the dynorphin system selectively,and the intermediate frequency works on promot-ing the release of enkephalin and β-endorphin,as well as dynorphin.Sparse-dense wave of EA may in-duce the release of enkephalin,β-endorphin,endomorphin and dynorphin,presenting a synergistic effect.However,the waveform of EA should be selected flexibly in clinical practice.Sometimes the better ther-apeutic effect can also be obtained with the continuous wave of EA.EOP system is involved in mediating appropriate intensity of EA,while the acupuncture effect generated by an extra strong EA stimulation refers to a kind of stress response of non-opioid mechanism.The different combinations of EA parame-ters result in various effects.The combination of EA parameters should be optimized in accordance with different diseases,which is valuable for guiding clinical practice and the development of EA therapy.

ElectroacupunctureEndogenous opioid systemStimulus parametersDose-effect relationship

陈平、徐红、张仁、田雪松

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上海中医药大学科技实验中心,上海 201203,中国

上海中医药大学附属龙华医院针灸科,上海 201203,中国

上海中医文献馆,上海 200025,中国

Electroacupuncture Endogenous opioid system Stimulus parameters Dose-effect relationship

National Natural Science Foundation of China6th Cycle Medical Key Specialty Construction Project of Jinshan DistrictThree Years Action Plan of Shanghai to Further Accelerate the Development of Traditional Chinese Medicine

81574078JSZK2019H042018-2020

2024

10.1016/j.wjam.2023.06.003

世界针灸杂志(英文版)
世界针灸学会联合会,中国中医研究院针灸研究所

世界针灸杂志(英文版)

CSTPCD
影响因子：0.375
ISSN：1003-5257
年,卷(期)：2024.34(1)
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