首页|针刺治疗偏头痛的效应机制研究:来自脑影像研究的证据(Ⅰ)

针刺治疗偏头痛的效应机制研究:来自脑影像研究的证据(Ⅰ)

Mechanistic investigation of acupuncture treatment in patients with migraine:Evidence from brain imaging study(Ⅰ)

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Objective:Magnetic resonance imaging(MRI)studies have demonstrated anatomical and functional al-terations of brain regions in patients with migraine,and the efficacy of acupuncture for migraine could regulate these abnormal alterations.However,its pathogenesis remains ambiguous,and inconsistent re-sults have been reported.The purpose of this study was to explore abnormal structural and functional alterations in patients with migraine using voxel-based morphometry(VBM)analysis and a seed-based functional connectivity(FC)approach and to provide a basis for future research.Methods:The study recruited 34 patients with migraine and 38 healthy controls who underwent struc-tural and resting-state functional magnetic resonance imaging(fMRI).VBM was evaluated across the whole brain,and group differences in the gray matter(GM)were compared.The significantly altered GM volumes considered as the seeding area were further calculated for the FC of the whole brain.The correlation between structural or functional changes of the brain and clinical features was also evaluated.Results:Patients with migraine manifested higher GM volumes in the left occipital lobe than healthy controls.Seed-based analyses demonstrated reduced FC between the left occipital lobe and right in-ferior frontal gyrus,extending to the anterior cingulate cortex(ACC)and right insula.Decreased FC in the left ACC was positively correlated with visual analog scale(VAS)and self-rating anxiety scale(SAS).Conclusions:This study indicated that patients with migraine exhibited abnormal changes in brain re-gions,which could facilitate a better understanding of how brain structure and function impact the symptoms of migraine and provide the basis for elucidating the potential mechanisms of acupuncture for migraine.Trial registration:Chinese Clinical Trial Registry,Chi CTR2000033995.Registered on 20 June 2020.

MigraineAcupunctureGray matterVoxel-based morphometryFunctional connectivityMagnetic resonance imaging

刘国韵、陈懿超、曹子敏、石安琪、许璐凡、李芷君、杨泽秋、闫超群、王军

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北京中医药大学东直门医院针灸科,北京 100700,中国

Migraine Acupuncture Gray matter Voxel-based morphometry Functional connectivity Magnetic resonance imaging

National Natural Science Foundation of China Youth FundDepartment of Science and Technology,National Administration of Traditional Chinese Medicinefifth batch of national research and training programs for clinical talents of traditional Chinese medicineProject for new teachers of Beijing University of Chinese Medicine

82004197GZY-KJS-2022-0292020-JYB-XJSJJ-045

2024

10.1016/j.wjam.2023.07.002

世界针灸杂志(英文版)
世界针灸学会联合会,中国中医研究院针灸研究所

世界针灸杂志(英文版)

CSTPCD
影响因子：0.375
ISSN：1003-5257
年,卷(期)：2024.34(1)
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