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针灸调节固有免疫治疗克罗恩病的研究进展

Research progress on acupuncture and moxibustion for treatment of Crohn's disease based on the regulation of innate immunity

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Crohn's disease(CD)is an inflammatory bowel disease whose pathogenesis remains unclear.In this paper,we reviewed the basic research of acupuncture and moxibustion in treating CD by regulating intestinal intrinsic immunity,and summarized in more detail that acupuncture and moxibustion can regulate the intestinal intrinsic immune system through the intestinal epithelial cell barrier,monocytes/macrophages,natural killer cells(NK cells),dendritic cells(DC),and neutrophils.Specifically,acupuncture and moxi-bustion can reduce the expression of inflammatory factors in the intestinal mucosa,alleviate intestinal fibrosis to repair the mechanical barrier of the intestinal mucosa,inhibit the expression of molecules of the MAPK,TLR/NF-κB signaling pathway and inflammatory factors,block the NK cell-mediated cytotox-icity pathway,and prevent the overactivation of neutrophils to control inflammatory responses,repair-ing the damaged intestinal tract and alleviating CD symptoms.This paper illustrated the characteristics of acupuncture and moxibustion for CD,which involves multi targets and pathways,aiming to provide guidance for the clinical application and basic research of acupuncture and moxibustion for CD.It also pointed out the current drawbacks of acupuncture and moxibustion therapy,and finally proposing the shortcomings of the current research,including the insufficient number of studies on acupuncture and moxibustion in the treatment of CD through the modulation of NK cells and neutrophils,the lack of standardization in acupuncture point selection,duration and treatment course,and the geographical lim-itations of the research locations for acupuncture and moxibustion in treating CD.

Crohn's diseaseInnate immunityAcupunctureMoxibustion

谢静、王文佳、侯瑜超、廖欧萍、黄思维、陆佳婧、刘慧荣、黄艳、李璟、吴焕淦

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上海中医药大学附属岳阳中西医结合医院,上海 200437,中国

上海针灸经络研究所,上海 200030,中国

Crohn's disease Innate immunity Acupuncture Moxibustion

国家自然科学基金国家自然科学基金Shanghai Key Clinical SpecialtyShanghai Science Foundation of ChinaSpecial Project for Clinical Research in the Health Industry of the Shanghai Municipal Health CommissionShanghai Sailing Program

8207454682205262shslczdzk0470121ZR146000020204024422YF1444100

2024

10.1016/j.wjam.2024.04.006

世界针灸杂志(英文版)
世界针灸学会联合会,中国中医研究院针灸研究所

世界针灸杂志(英文版)

CSTPCD
影响因子：0.375
ISSN：1003-5257
年,卷(期)：2024.34(2)
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