首页|针刺调节小胶质细胞活化治疗阿尔茨海默病:神经炎症机制研究进展

针刺调节小胶质细胞活化治疗阿尔茨海默病:神经炎症机制研究进展

Acupuncture regulating microglial activation in Alzheimer's disease:Research progress in its neuroinflammation mechanism

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Microglia(MG)activation and its mediated neuroinflammation are closely related to the occurrence and deterioration of Alzheimer's disease(AD).Acupuncture is one of the effective approach for AD,which can relieve the symptoms and slow the deterioration of AD.Based on the role of MG activation and its induced pro-inflammatory and anti-inflammatory phenotypes in neuroinflammation,this paper reviews the related literature on the mechanism of acupuncture in regulating MG activation and relieving neu-roinflammation in AD.It is found that acupuncture can inhibit abnormal MG activation by regulating the release of MG surface immune receptors and pro-inflammatory/anti-inflammatory cytokines.It can also modulate the activity of signaling pathways associated with MG polarization,downregulate the ex-pression of M1,and promote MG polarization towards the M2 phenotype.Additionally,it adjusts the imbalance between M1 and M2 phenotypes of MG,thereby relieving the neuroinflammatory pathological procession of and repairing the neuronal damage so as to achieve its therapeutic effect.

Alzheimer's diseaseAcupunctureMicroglia cellMechanism

魏玉婷、苏明莉、任德琳、张鑫、朱田田、严兴科

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甘肃中医药大学针灸推拿学院,兰州,730000,中国

Alzheimer's disease Acupuncture Microglia cell Mechanism

Scientific Research and Innovation Fund Project of Gansu University of Chinese MedicineYouth Doctoral Fund Project of Gansu Provincial Department of EducationTalent Research Startup Fund Project of Gansu University of Chinese Medicine

2022KCYB-72021QB-0722019YJRC-05

2024

10.1016/j.wjam.2024.04.004

世界针灸杂志(英文版)
世界针灸学会联合会,中国中医研究院针灸研究所

世界针灸杂志(英文版)

CSTPCD
影响因子：0.375
ISSN：1003-5257
年,卷(期)：2024.34(2)
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