首页|针灸辅助改善冻融胚胎移植疗效的网状Meta分析

针灸辅助改善冻融胚胎移植疗效的网状Meta分析

Effect of acupuncture and moxibustion as the adjuvant therapy on frozen-thawed embryo transfer:A network meta-analysis

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Objective:To evaluate the clinical effect of acupuncture-moxibustion as the adjuvant therapy on frozen-thawed embryo transfer(FET)using network meta-analysis.Methods:In PubMed,Embase,Cochrane Library,Chinese National Knowledge Infrastructure(CNKI),Wan-fang database(WanFang),VIP database and Chinese Biomedical Literature Database(SinoMed),the ran-domized controlled trials(RCTs)of the adjuvant therapy of acupuncture-moxibustion for FET were re-trieved,from database inception to April 1,2021.Cochrane risk of bias assessment tool was used to screen and evaluate the quality of the included studies,and RevMan 5.3,GeMTC0.14.3 and Stata16.0 software were adopted to complete the network meta-analysis.Results:Twenty-nine RCTs comprising 2880 patients were finally included,involving 17 interven-tions and 4 outcome measures.The results of network meta-analysis showed that the top three ther-apies under each outcome based on the magnitude of SUCRA values were:① Clinical pregnancy rate(CPR,％):"transcutaneous electrical acupoint stimulation+herbal medicine"(76.4),"moxibus-tion+herbal medicine"(74.7),"acupuncture+moxibustion"(73.3);②Biochemical pregnancy rate(BPR):"moxibustion+herbal medicine"(89.3),"acupuncture+moxibustion"(82.1),"acupuncture+herbal medicine"(78.7);③Endometrial thickness:"acupoint injection+Western medicine"(87.2),auricular therapy(76.8),"acupuncture+herbal medicine"(73.5);④Type A endometrial morphology rate:"acu-point injection+Western medicine"(78.3),"moxibustion+herbal medicine"(58.0)and"acupunc-ture+moxibustion"(52.6).Conclusion:The combined treatment of acupuncture-moxibustion was superior to single therapy for FET patients.The combined therapy of transcutaneous electrical acupoint stimulation and herbal medicine had the best effect for improving CPR,"moxibustion+herbal medicine"obtained the best average com-prehensive effect,and"acupoint injection+Western medicine"was conductive to ameliorate the en-dometrial thickness and morphology.Due to the limitations of existing studies,more high-quality RCTs are needed in the future to further verify these conclusions.

AcupunctureMoxibustionFrozen-thawed embryo transferPregnancy rateEndometrium thicknessEndometrial morphologyNetwork meta-analysis

罗敏辉、谭艳、左耀辰、石文英、王鑫、章薇

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湖南中医药大学,长沙 410208,中国

湖南中医药大学第一附属医院,长沙 410007,中国

Acupuncture Moxibustion Frozen-thawed embryo transfer Pregnancy rate Endometrium thickness Endometrial morphology Network meta-analysis

TCM Evidence-Based Capacity Construction ProjectNational Administration of Traditional Chinese Medicine(2019)国家重点研发计划

2019XZZX-ZJ0072019YFC1709104

2024

10.1016/j.wjam.2024.04.003

世界针灸杂志(英文版)
世界针灸学会联合会,中国中医研究院针灸研究所

世界针灸杂志(英文版)

CSTPCD
影响因子：0.375
ISSN：1003-5257
年,卷(期)：2024.34(2)
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