Study on the Dexamethasone Palmitate Molecular Structure by Derivative Middle Infrared Spectroscopy
Mid infrared(MIR)spectroscopy are used to study the molecular structure of dexamethasone palmitate(DXP).The experiment finds that the infrared absorption mode of dexamethasone palmitate molecular structure mainly includes:C—H stretching vibration mode(νCH-DXP),CH3 groups asymmetric stretching vibration mode(νasCH3-DXP),CH2 group asymmetric stretching vibration mode(νasCH2-DXP),CH2 group symmetric stretching vibration mode(νsCH2-DXP),C=O group stretching vibration mode(νC=o-DxP),C=C group stretching vibration mode(νC=C-DXP),CH2 group bending vibration mode(δCH2-DXP),CH3 group symmetric bending vibration mode(δsCH3-DXP)and CH2 group rocking vibration mode(ρCH2-DXP).The original spectrum of dexamethasone palmitate is processed at different orders(including first,second,third,and fourth orders),and the spectral resolution of the second derivative MIR spectrum is better than that of other derivative MIR spectra,The second-order derivative MIR spectra exhibits certain differences at different smoothing points(including 5 smoothing points,9 smoothing points,13 smoothing points,19 smoothing points,25 smoothing points,37 smoothing points,49 smoothing points,and 149 smoothing points).Among them,the second-order derivative MIR spectra of 5 smoothing points provides the richest spectral information,but as the number of smoothing points increases,the spectral resolution of the second-order derivative MIR spectra further decreases.
dexamethasone palmitateone dimensional MIR spectroscopysecond-order derivative MIR spectroscopystructure
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维普
