Clinical Efficacy of Modified Dingchuan Decoction Combined with Glucocorticoid for Pediatric Bronchial Asthma with Lung-Spleen Qi Deficiency Type and Its Im-pact on Airway Remodeling and Serum TGFβ Levels
Objective To explore the effect of modified Dingchuan Decoction combined with glucocorticoid on airway remodeling and serum transforming growth factor β(TGFβ)in children with bronchial asthma of lung-spleen qi de-ficiency.Methods A total of 82 children with lung-spleen qi deficiency type bronchial asthma admitted to The First Af-filiated Hospital of Henan University from January 2022 to December 2022 were randomly divided into a control group and an observation group according to random number table method,with 41 cases in each group.The control group was treated with glucocorticoid inhalation therapy,and the observation group was treated with Dingchuan Decoction in addition to the treatment in the control group.After 3 months of treatment,the clinical efficacy,incidence of adverse reactions,the scores of traditional Chinese medicine(TCM)symptoms before and after treatment,airway remodeling indicators[total bronchial area(TA),wall area(WA),lumen area(LA)],and serum indicators[interleukin-4(IL-4),interleukin-5(IL-5),TGFβ]were observed and compared between the two groups.Results The total effective rates in the observation group af-ter treatment was 92.68％(38/41),significantly higher than the control group's 75.61％(31/41),with a statistically sig-nificant difference(P＜0.05).After treatment,the scores of wheezing,shortness of breath and dyspnea in the both groups were significantly reduced compared to before treatment,with statistically significant differences(P＜0.05).Moreover,the observation group had significantly lower scores for wheezing,shortness of breath,and dyspnea compared to the control group(P＜0.05).After treatment,the levels of TA,WA and LA in both groups were significantly reduced compared to be-fore treatment(P＜0.05).The observation group had significantly lower airway remodeling indicators(TA,WA,LA)than the control group(P＜0.05).After treatment,the serum levels of IL-4,IL-5 and TGFβ in both groups were significantly lower compared to before treatment(P＜0.05).The observation group had significantly lower serum levels of IL-4,IL-5,and TGFβ compared to the control group(P＜0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Dingchuan decoction combined with glucocorticoid in the treatment of children with bronchial asthma with lung-spleen Qi deficiency can significantly reduce the level of TGFβ,reverse airway remodeling and improve clinical therapeutic effect.
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