Clinical Efficacy of Modified Sijunzi Decoction in Treatment of Patients with Ulcera-tive Colitis and Its Regulatory Effect on Intestinal flora
Objective To observe the clinical efficacy of modified Sijunzi Decoction in the treatment of patients with ulcerative colitis(UC)and its regulatory effect on the intestinal flora.Methods The clinical data of 106 patients with chronic UC admitted to Department of Proctology of Chongqing University Three Gorges Hospital from January 2020 to June 2022 were retrospectively analyzed.According to the different treatment plans,They were divided into two groups a control group and an observation group,with 53 cases in each group.The control group received conventional Western medicine comprehensive treatment,while the observation group received modified Sijunzi Decoction treatment in addition to the treat-ment in the control group.After 12 weeks of treatment,T clinical efficacy a(syndromic efficacy,mucosal lesion efficacy),incidence of adverse reactions,follow-up outcomes,and major outcome indicators before and after treatment(colonoscopic mucosal presentation,histopathology),secondary outcome indicators[Sutherland Disease Activity Index(DAI),traditional Chinese medicine syndrome score,Inflammatory Bowel Disease Questionnaire(IBDQ)],and intestinal flora detection(Bifidobacterium,Lactobacillus,Escherichia coli,and Enterococcus)was compared and analyzed.Results After treat-ment,the total effective rate of traditional Chinese medicine syndrome efficacy in the observation group were 96.23％(51/53),significantly higher than 83.02％(44/53)in the control group,with a statistically significant difference(x2=8.016,P=0.005).The total effective rate of mucosal lesion efficacy in the observation group was 92.45％(49/53),significantly higher than 81.13％(43/53)in the control group,with a statistically significant difference(x2=4.645,P=0.031).After treatment,both groups showed a decrease in traditional Chinese medical syndrome and lesion scores(DAI,colonoscopy score,and histopathological score),and increase in IBDQ score compared to before treatment,with statistically significant differences(P＜0.05).The observation group had significantly lower scores for traditional Chinese medicine syndrome and lesion severity(DAI,colonoscopy,histopathology)and significantly higher IBDQ scores compared to the control group,with statistically significant differences(P＜0.05).After treatment,both groups showed an increase in the content of Bifidobac-terium and Lactobacillus,and a decrease in the content of Escherichia coli and Enterococcus,with statistically significant differences(P＜0.05).The observation group had a significantly higher content of Bifidobacterium and Lactobacillus,and a significantly lower content of Escherichia coli and Enterococcus compared to the control group,with statistically signifi-cant differences(P＜0.05).During the treatment period,the incidence of adverse reactions was comparable between the two groups,with no statistically significant difference(x2=0.141,P=0.707).At a 6-month follow-up,the recurrence rate in the observation group was 3.92％(2/51),significantly lower than 22.73％(10/44)in the control group,with a sta-tistically significant difference(x2=14.321,P＜0.001).Conclusion Modified Sijunzi Decoction can regulate intestinal flora,promote symptom relief and intestinal mucosal repair,improve short-term efficacy and reduce recurrence rate in the treatment of chronic UC.
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