Efficacy and imaging Evaluation of Guijia Jiangu Capsule in the Treatment of Senile Osteoporotic Vertebral Compression Fracture
Objective To explore the efficacy of Guijia Jiangu capsule on senile osteoporotic vertebral compres-sion fracture(OVCF).Methods A toal of 206 elderly OVCF patients admitted to Nanchong Traditional Chinese Medicine Hospital from November 2021 to October 2022 were selected as the research subjects.They were randomly divided into an observation group and a control group using a random number table method,with 103 cases in each group,.Both groups un-derwent percutaneous vertebroplasty,with the control group receiving conventional Western medicine after surgery,and the observation group receiving a combination of Western medicine and Guijia Jiangu capsules.After 3 months of treatment,the clinical efficacy,fracture healing time,incidence of complications,pre and postoperative vertebral anterior and posterior heights,Cobb angle,and serum levels of hypoxia-inducible factor 1(HIF-1α),vascular endothelial growth factor(VEGF),bone metabolism indicators[alkaline phosphatase(ALP),bone gamma-carboxyglutamic-acid-containing proteins(BGP),bone mineral density(BMD)]and Oswestry Disability Index(ODI)scores were observed and compared between the two groups of patients.Results After 3 months of surgery,the vertebral anterior and posterior heights of the two groups were significantly higher than before surgery,and the Cobb angle was significantly reduced compared to before surgery,with a statistically significant difference(P＜0.05).The heights of the vertebral anterior and posterior bodies in the observation group were significantly higher than that in the control group,with statistical significance(P＜0.05).The Cobb angle was similar to that in the control group,with no statistical significance(P＞0.05).After 3 months,both groups showed a signifi-cant increase in serum HIF-1 and VEGF levels compared to before surgery(P＜0.05),and the observation group's serum HIF-1αand VEGF levels were significantly higher than those of the control group,and the difference was statistically sig-nificant(P＜0.05).The fracture healing time in the postoperative observation group was significantly shorter than that in the control group,and the difference was statistically significant(P＜0.05).After 3 months of surgery,the levels of ALP,BGP,and BMD in the two groups of patients increased significantly compared to before surgery(P＜0.05);And the obser-vation group was significantly higher than the control group,with a statistically significant difference(P＜0.05).After 3 months of surgery,the ODI scores in both groups of patients decreased significantly compared to before surgery(P＜0.05);The ODI score of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the total effective rate of the observation group was 92.23％(95/103),which was significantly higher than that of the control group of 75.73％(78/103),and the difference was statistically sig-nificant(P＜0.05).During the treatment period,neither group of patients experienced bone cement leakage or epidural he-matoma;The incidence of secondary fractures in the observation group after treatment was 1.94％(2/103),which was sig-nificantly lower than that in the control group at 12.62％(13/103),and the difference was statistically significant(P＜0.05).Conclusion Guijia Jiangu capsule as an adjuvant treatment for elderly OVCF can effectively regulate bone metab-olism,promote bone formation,improve bone density,accelerate fracture healing and enhance postoperative recovery of ver-tebral function,reducing the risk of secondary fracture.
万方数据
维普
