摘要
目的 基于数据挖掘技术总结古代中医药治疗癫痫的用药规律.方法 利用古今医案云平台(V2.3.8)检索自1912年1月1日前的古代癫痫医案,对符合标准的医案提取中药数据,使用Microsoft Excel 2019建立标准医案数据库,进行频数分析、关联规则分析、聚类分析以及复杂网络分析,总结古代医家治疗癫痫的用药规律.结果 共纳入癫痫医案192则,涉及中药244味,累计频数1975次,排名前五位药物为:胆南星(69次,35.94％),陈皮(68 次,35.42％),半夏(61 次,31.77％),石菖蒲(59 次,30.73％),甘草(54 次,28.12％)等,药物性味多属温、寒、平性,甘、苦、辛味,归心、肺、肝经.排名前五位中药功效依次为:补虚药、化痰止咳平喘药、清热药、安神药、理气药.关联强度前五位药对为:半夏-陈皮,石菖蒲-胆南星,远志-石菖蒲,钩藤-陈皮,郁金-胆南星等,通过复杂网络分析,得出核心处方组合:陈皮,半夏,胆南星,石菖蒲,远志,甘草,当归,钩藤,茯神,人参,茯苓,郁金,朱砂.结论 古代医家用药谨守扶正祛邪原则,重视补虚药和化痰药的使用,挖掘出以定痫丸化裁的核心方,为癫痫临床用药提供数据支持.
Abstract
Objective To summarize the prescription rule in the treatment of epilepsy in ancient Chinese medi-cine based on data mining.Methods Ancient medical records on epilepsy before January 1,1912 were retrieved by the Ancient and Modern Medical Case Cloud Platform(V2.3.8).Chinese herbal medicine data from the records that met the criteria were extracted,and a standard medical record database was established using Microsoft Excel 2019.Frequency a-nalysis,association rule analysis,cluster analysis,and complex network analysis were conducted to summarize the prescrip-tion rule of ancient practitioners in the treatment of epilepsy.Results A total of 192 epilepsy medical records were includ-ed,involving 244 herbal medicines with a cumulative usage frequency of 1 975.The top five used herbal medicines by us-age frequency were Arisaema cum Bile(69 times,35.94％),Pericarpium Citri Reticulatae(68 times,35.42％),Rhizoma Pinelliae(61 times,31.77％),Rhizoma Acori Tatarinowii(59 times,30.73％),and Radix Et Rhizoma Glycyrrhizae(54 times,28.12％).The herbs were mainly warm,cold,and moderate in nature,and sweet,bitter,and pungent in flavor,acting on the heart,lung,and liver meridians.The top five effects were tonifying,resolving phlegm and relieving cough and dyspnea,clearing heat,tranquilizing mind,and regulating qi.The top five herbal pairs in terms of association strength in-cluded Rhizoma Pinelliae-Pericarpium Citri Reticulatae,Rhizoma Acori Tatarinowii-Arisaema cum Bile,Radix Polygalae-Rhizoma Acori Tatarinowii,Ramulus Uncariae cum Uncis-Pericarpium Citri Reticulatae,and Radix Curcumae-Arisae-ma cum Bile.Complex network analysis identified the core prescription combinations:Pericarpium Citri Reticulatae,Rhizo-ma Pinelliae,Arisaema cum Bile,Rhizoma Acori Tatarinowii,Poly gala,Radix Et Rhizoma Glycyrrhizae,Radix Angelicae Sinensis,Ramulus Uncariae cum Uncis,poria with hostwood(Fu Shen),Radix et Rhizoma Ginseng,Poria,Radix Curcum-ae,and Cinnabaris.Conclusion Ancient physicians strictly followed the principle of reinforcing healthy qi to eliminate pathogens,emphasizing the use of tonifying and phlegm-resolving medicines.They established foundational prescriptions,such as modified Dingxian Pill,providing data support for the clinical medication of epilepsy.
基金项目
中央高校基本科研业务费专项(2020-JYB-ZDGG-133)
国家自然科学基金资助项目(81774277)
维普
万方数据