Efficacy and Safety of Danlou Tablets Combined with Western Medicine in the Treatment of Coronary Heart Disease:A Meta-analysis
Objective To systematically evaluate the efficacy of Danlou Tablets in combination with western med-icine versus single western medicine in the treatment of coronary artery disease,and to provide an evidence-based refer-ence for clinical practice.Methods PubMed,Embase,Cochrane Library,China Biomedical Literature Service System(Si-nomed),China National Knowledge Infrastructure(CNKI),China Scientific and Technological Journal Database(VIP),and Wanfang Data were searched to comprehensively collect randomized controlled trials(RCTs)comparing Danlou Tablets combined with conventional medicine(treatment group)to single conventional medicine(control group)in the treatment of coronary artery disease.The retrieval time was from 2017 to June 20,2023.The quality of the included studies was assessed using the Cochrane Risk of Bias Assessment Tool,and analysis was performed with RevMan 5.4.Results Fourteen RCTs involving a total of 1 292 patients were included.The meta-analysis revealed that the treatment group had significantly better outcomes in several aspects:clinical efficacy[RR=1.24,95%CI(1.17,1.31),P<0.000 01];improvement in ST-segment depression[MD=0.66,95%CI(0.53,0.80),P<0.000 01];T-wave inversion[MD=0.25,95%CI(0.03,0.46),P=0.03];ECG improvement[RR=1.20,95%CI(1.02,1.41),P=0.03];nitroglycerin reduction[RR=1.34,95%CI(1.12,1.34),P=0.002];angina attack frequency[MD=1.43,95%CI(0.61,2.25),P=0.000 7];duration of angina[MD=2.78,95%CI(1.79,3.76),P<0.000 01];incidence of adverse reactions[RR=0.42,95%CI(0.24,0.76),P=0.004];traditional Chinese medicine syndrome scores[MD=4.47,95%CI(1.75,7.18),P<0.000 1].Con-clusion Danlou Tablets combined with conventional treatment regimens can enhance the effectiveness of most clinical in-dices and symptoms with a degree of safety.However,due to the low quality and small sample sizes of the included studies,more rigorously designed,scientifically implemented,large-sample,high-quality RCTs are needed to further assess and validate the findings and to provide reliable evidence for guiding clinical pharmacotherapy.
Danlou TabletsCoronary heart diseaseIntegrated traditional Chinese and western medicineSafetyMeta-analysis