Effect of Jiawei Erxian Decoction on Insulin Resistance and Sex Hormone Levels in Infertile Patients with Polycystic Ovary Syndrome
Objective To investigate the effect of Jiawei Erxian decoction on insulin resistance and sex hormone levels in infertility patients with polycystic ovary syndrome(PCOS).Method A total of 120 patients with PCOS infertility treated in Puyang Maternal and Child Health Hospital of Henan Province from January 2020 to January 2022 were selected as the study objects and randomly divided into a control group and an observation group,with 60 cases in each group.The control group was treated with metformin,and the observation group was treated with Jiawei Erxian decoction in addition to the treatment given to the control group.One menstrual cycle was considered as one course of treatment,and both groups underwent 3 courses of treatment.The clinical efficacy,fasting plasma glucose(FPG),fasting insulin(FINS)and homeosta-sis model insulin resistance index(HOMA-IR),sex hormone levels[estradiol(E2),follicle stimulating hormone(FSH),testosterone(T),and luteinizing hormone(LH)],changes in uterine and ovarian function[ovarian volume,endometrial thickness,number of mature follicles],and post-treatment ovulation,pregnancy,and recurrence before and after treatment were compared between the two groups.Results After treatment,the total effective rate in the observation group was 96.67%(58/60),which was higher than the control group's 85.00%(51/60),with a statistically significant difference(P<0.05).After treatment,the insulin indicators FPG,FINS,and HOMA-IR in both groups significantly decreased compared to before treatment,with statistically significant differences(P<0.05);the insulin indicators FPG,FINS,and HOMA-IR in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,After treatment,the hormone levels E2,FSH,T,and LH in both groups significantly decreased compared to before treatment,with statistically significant differences(P<0.05);additionally,the hormone lev-els E2,FSH,T,and LH in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,ovarian volume decreased while endometrial thickness and the number of mature follicles increased compared to before treatment,with statistically significant differences(P<0.05)in both groups.Moreover,the observation group had a significantly lower ovarian volume and significantly higher endometrial thick-ness and number of mature follicles compared to the control group,with statistically significant differences(P<0.05).Dur-ing the 3-month follow-up period,the ovulation rate in the observation group was 86.67%(52/60),and the pregnancy rate was 76.67%(46/60),both of which were higher than those in the control group,which were 71.67%(43/60)and 58.33%(35/60)respectively.The recurrence rate in the observation group was 1.67%(1/60),lower than the control group's 11.67%(7/60),with statistically significant differences(P<0.05).Conclusion The clinical effect of Jiawei Erxian Decoction in treating PCOS is significant.It can effectively reduce the insulin resistance and regulate the level of sex hormones,improve ovarian function,promote ovulation,and increase the success rate of pregnancy.Therefore,Jiawei Erxian Decoction is worthy of clinical promotion.