The Relationship between Syndrome of Upper Energizer Diseases,Overflow Pulse and Inflammation
Objective Pulse diagnosis is a very distinctive diagnostic method in traditional Chinese medicine.O-verflow pulse is s a relatively understudied aspect of pulse diagnosis in clinical research.Analyzing the relationship between overflow pulse and inflammatory reactions in patients with upper energizer diseases contributes to enriching the value of o-verflow pulse in clinical diagnosis and treatment.Methods A total of 1151 outpatients with upper energizer disease trea-ted at Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from March 15,2019 to July 31,2022 were collected as the case group,and 1000 healthy volunteers at the same period were selected as the control group.The relationship between the occurrence of overflow pulse and inflammatory reaction was compared between the two groups.Results Compared with the control group,the incidence of overflow pulse in the case group was significantly high-er,along with elevated levels of interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α),with statistically significant differences(P＜0.05).Compared with the control group with overflow pulse,the peripheral blood IL-1,IL-6 and TNF-α in the case group with overflow pulse were significantly increased(P＜0.05).Compared with the control group without overflow pulse,the peripheral blood IL-1,IL-6 and TNF-α in the case group without o-verflow pulse were significantly elevated(P＜0.05).Compared with the case group without overflow pulse,the peripheral blood IL-1,IL-6 and TNF-α in the case group with overflow pulse were significantly elevated(P＜0.05).Among 899 cases of overflow pulse,797 cases exhibited single pulse(88.65％),and 102 cases exhibited complex pulse(11.35％).A-mong the single pulse cases,539 cases were unsmooth pulse(59.96％),89 cases were slippery pulse(9.90％),68 cases were replete pulse(7.56％),56 cases were wiry pulse(6.23％),and 45 cases were surging pulse(5.01％).Among the complex pulse cases,89 cases were slippery-replete pulse(9.90％),and 13 cases were surging-wiry pulse(1.45％).Compared with the single pulse cases,the IL-1,IL-6 and TNF-α levels in the complex pulse cases were significantly higher(P＜0.05).The levels of IL-1,IL-6 and TNF-α in unsmooth pulse,slippery pulse and replete pulse cases were significantly higher as compared with those in single pulse cases(P＜0.05).The proportion of overflow pulse occurrence was higher in patients with upper energizer diseases including insomnia,anxiety disorder,oronasopharynx diseases,thyroid and breast diseases,hypertension,gastroesophageal reflux disease,and intracranial diseases,with statistically significant differences(P＜0.05).Moreover,the levels of IL-1,IL-6,and TNF-α in peripheral blood were also higher in these patients(P＜0.05).Conclusion Overflow pulse is not a physiological pulse,and its occurrence is closely related to up-per energizer diseases,accompanied by remarkable inflammatory responses.Among the associated symptoms,insomnia and anxiety are the most common,followed by oronasopharynx diseases,which may not be related to respiratory wheezing.Therefore,it is critical to pay attention to the detection of overflow pulse in clinical pulse diagnosis.
万方数据
维普
