Clinical Observation of Fire-Needle Warming and Dredging Combined with Com-pound Kaliziran Tincture in the Treatment of Vitiligo in the Stable Phase
Objective To evaluate the clinical efficacy of fire-needle warming and dredging combined with com-pound Kaliziran Tincture in the treatment of patients with vitiligo in the stable phase.Methods Between August 2020 and August 2021,90 patients with vitiligo in the stable phase from the Outpatient Department of Henan Provincial Hospital of Traditional Chinese Medicine were selected and divided into a phototherapy group and a traditional Chinese medicine(TCM)group by a random number table,with 45 in each group.The phototherapy group was treated with 308 nm excimer laser,while the TCM group underwent fire-needle warming and dredging combined with compound Kaliziran Tincture.The treatment lasted for three courses,each course for one month.Clinical efficacy,adverse reactions within 24 hours after the initial phototherapy/fire needling,changes in lesion recovery,serum inflammatory and immune markers[Interleukin-1β(IL-1 β),Nuclear Factor-kappa B(NF-κB),Immunoglobulin A(IgA),and Immunoglobulin G(IgG)],and Dermatol-ogy Life Quality Index(DLQI)scores were compared between the two groups before and after treatment.Results The total effective rate of the TCM group(95.00％,38/40)was not significantly different from that of the phototherapy group(88.37％,38/43)(P＞0.05).Both groups presented a reduction in lesion area and an improvement in serum inflamma-tion and immune markers after treatment(P＜0.05),with the TCM group exhibiting greater reductions and improvements(P＜0.05).The degree of pigment recovery at the target site was better in the TCM group than the phototherapy group(P＜0.05).DLQI scores were reduced in both groups post-treatment(P＜0.05),while no obvious difference was observed between the two groups(P＞0.05).There were no significant differences in the incidence of adverse skin reactions be-tween the phototherapy group and TCM group(13.95％,6/43 vs.13.95％,6/43)(P＞0.05).Conclusion Fire-needle warming and dredging combined with compound Kaliziran Tincture in the treatment of vitiligo in the stable phase showed promise in clinical efficacy,which markedly promoted lesion recovery and regulated serum inflammatory and immune fac-tors,with high safety.
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