Efficacy and Safety of Jiangniaosuan Fangtongfeng Drink in the Treatment of 30 Pa-tients with Chronic Refractory Gouty Arthritis(Turbid Phlegm Obstruction)Com-plicated with Hyperlipidemia
Objective To assess the efficacy and safety of Jiangniaosuan Fangtongfeng Drink in the treatment of 30 patients with chronic refractory gouty arthritis characterized by turbid phlegm obstruction,complicated with hyperlipi-demia.Methods Sixty patients with chronic refractory gouty arthritis and hyperlipidemia who were treated at Huizhou Hospital of Guangzhou University of Chinese Medicine from December 2021 to December 2022 were enrolled as study sub-jects.They were divided into a Western medicine group and a combination group by a random number table,with 30 in each group.The Western medicine group received meloxicam tablets,while the combination group received Jiangniaosuan Fangtongfeng Drink in addition to Western medicine.After 28 days of treatment,clinical efficacy,adverse reactions,tradi-tional Chinese medicine(TCM)syndrome scores,visual analogue scale(VAS)scores,blood uric acid(BUA),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),total cholesterol(TC),and triglycerides(TG)before and after treat-ment were compared between the two groups.Results The combination group showed a higher total effective rate of 93.33％(28/30)compared with the Western medicine group of 70.00％(21/30)(P＜0.05).After 14 and 28 days of treatment,the TCM syndrome scores and VAS scores decreased in both groups compared with the conditions before treat-ment(P＜0.05),and the combination group had lower scores than the Western medicine group(P＜0.05).Additionally,the BUA level in both groups decreased after treatment(P＜0.05),with the combination group showing a greater reduction than the Western medicine group(P＜0.05),and the BUA after 28 days of treatment was lower than that after 14 days of treatment(P＜0.05).Both groups had down-regulated CRP,ESR,TC,and TG levels after 28 days of treatment(P＜0.05),with the combination group having lower levels than the Western medicine group(P＜0.05).There was no signifi-cant difference in the incidence of adverse reactions between the two groups(x2=1.071,P=0.301).Conclusion Jiang-niaosuan Fangtongfeng Drink would significantly improve the clinical symptoms,treatment outcomes,and laboratory indexes in patients with chronic refractory gouty arthritis and hyperlipidemia characterized with turbid phlegm obstruction,while ef-fectively relieving joint pain and demonstrating safety and reliability.
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