Meta-analysis of Clinical Efficacy of Zhenwu Decoction in Treating Dilated Cardio-myopathy
Objective To systematically evaluate the clinical efficacy of Zhenwu Decoction in treating dilated car-diomyopathy.Methods The studies about the treatment of dilated cardiomyopathy with modified Zhenwu Decoction were retrieved from Wanfang Data,VIP,China National Knowledge Infrastructure(CNKI),and PubMed with the time interval from January 1,2000 to October 31,2023.Meta-analysis was carried out with the fixed effect model for homogenous stud-ies and the random effect model for heterogeneous studies.Revman5.3 was used to evaluate the quality of the included studies.Statal5.1 was employed to analyze the data,and TSA 0.9 was used for sequential analysis of the response rate.Results A total of 12 randomized controlled trials(RCTs)were included,involving 666 patients.The results of meta-a-nalysis showed that modified Zhenwu Decoction combined with Western medicine outperformed Western medicine alone in elevating the left ventricular ejection fraction(SMD=4.27,95%CI:2.07-6.48,P<0.000 1),reducing the left ventricu-lar end-diastolic diameter(SMD=-7.74,95%CI:-8.37 to-7.11,P<0.000 01),and improving the total response rate(OR=3.62,95%CI:2.16-6.08,P<0.000 1)in the patients with dilated cardiomyopathy.Conclusion Zhenwu Decoction combined with Western medicine is superior to Western medicine alone in elevating left ventricular ejection frac-tion,reducing left ventricular end-diastolic diameter,and improving the total response rate in the treatment of dilated car-diomyopathy.