目的 纳入系统评价康复新液联合质子泵抑制剂(Proton pump inhibitor,PPI)治疗反流性食管炎(Reflux esophagitis,RE)相较于单独使用PPI的疗效和安全性评价.方法 以康复新液、反流性食管炎、反流性食道炎、KangFuXin、reflux esophagitis 等为检索词在 CNKI、WanFang Data、VIP、Embase、Web of Science、PubMed 和 The Cochrane Library数据库检索康复新液联合PPI治疗RE的随机对照研究,采用RevMan 5.4软件进行Meta分析.结果 共纳入25项研究,统计分析结果显示康复新液联合PPI治疗RE较单独PPI治疗能显著提高临床有效率(95％CI:1.15,1.24)、胃镜下有效率(95％CI:1.14,1.22),血清胃泌素(95％CI:1.15,2.03)和胃动素的分泌(95％CI:0.96,1.39),降低复发率(95％CI:0.20,0.61),且不会增高不良反应发生率(95％CI:0.33～0.79),此外,不同PPI种类以及患者年龄高低对临床有效率无显著影响,而不同内镜下诊断标准对内镜下有效率也无显著影响.结论 康复新液联合PPI治疗RE较单独PPI治疗能取得更好的疗效且减少疾病复发,并不会额外造成不良反应的发生.
Efficacy and Safety Evaluation of Kangfuxin with PPI in the Treatment of Reflux Esophagitis:A Meta-analysis
Objective To evaluate the efficacy and safety of Kangfuxin combined with proton pump inhibitors(PPIs)compared to using PPIs alone in the treatment of reflux esophagitis(RE)through systematic review.Methods U-sing keywords such as"康复新液(Kangfuxin)","反流性食管炎(reflux esophagitis)",Kangfuxin,and reflux esophagi-tis,relevant randomized controlled trials on the treatment of RE with Kangfuxin combined with PPIs were searched in data-bases including CNKI,WanFang Data,VIP,Embase,Web of Science,PubMed,and The Cochrane Library.Meta-analysis was conducted using RevMan 5.4 software.Results A total of 25 studies were included.The statistical analysis showed that Kangfuxin combined with PPIs significantly improved the clinical efficacy(95％CI:1.15,1.24),endoscopic efficacy(95％CI:1.14,1.22),serum gastrin(95％CI:1.15,2.03),and motilin secretion(95％CI:0.96,1.39)compared to u-sing PPIs alone.Moreover,it also reduced the recurrence rate(95％CI:0.20,0.61)without increasing the incidence of ad-verse reactions(95％CI:0.33-0.79).Furthermore,different types of PPIs and patient age did not significantly affect clinical efficacy,while different endoscopic diagnostic criteria did not significantly affect endoscopic efficacy.Conclusion Kangfuxin combined with PPIs achieved better efficacy in treating RE compared to using PPIs alone,reduced the recur-rence of the disease,and did not lead to additional adverse reactions.
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