Jinrong Granules Combined with Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer:Clinical Efficacy and Effects on Levels of Angiogenesis-Related Fac-tors,Oxidative Stress,and Tumor Markers
Objective To investigate the clinical efficacy of Jinrong Granules combined with neoadjuvant chemo-therapy in the patients with triple-negative breast cancer(TNBC)and the effects of this treatment regimen on the levels of angiogenesis-related factors,oxidative stress,and tumor markers.Methods A total of 94 TNBC patients treated in the Zhujiang Hospital of Southern Medical University from April 2020 to April 2022 were selected and assigned into a control group and an observation group by the random number table method,with 47 patients in each group.The control group was treated with TAC(taxotere,adriamycin,and cyclophosphamide)chemotherapy,and the observation group with Jinrong Gran-ules on the basis of the therapy in the control group.Each treatment course lasted for 21 days,and both groups were treated for 4 consecutive courses.The two groups were compared in terms of clinical efficacy,World Health Organization quality of life-brief(WHOQOL-BREF)score,angiogenesis-related factors[vascular endothelial growth factor(VEGF)and vascu-lar endothelial growth factor receptor 2(VEGFR2)],oxidative stress indicators[malondialdehyde(MDA),superoxide dis-mutase(SOD),nitric oxide(NO),and glutathione peroxidase(GSH-PX)],tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),and carbohydrate antigen 153(CA153)],and T lymphocyte subsets(CD4+,CD8+,and CD4+/CD8+)].Results After treatment,the total response rate in the observation group was 91.49％(43/47),which was higher than that(76.60％,36/47)in the control group(P＜0.05).After treatment,the scores of all dimensions in the WHOQOL-BREF rose compared with those before treatment(P＜0.05),and the observation group had higher scores than the control group(P＜0.05).The treatment in both groups lowered the levels of CA125,CA153,and CEA(P＜0.05),and the observation group had lower levels than the control group after treatment(P＜0.05).The treat-ment in both groups elevated the MDA level and lowered the SOD,NO,and GSH-PX levels(P＜0.05),and the observa-tion group had higher MDA level and lower SOD,NO,and GSH-PX levels than the control group(P＜0.05).After treat-ment,the levels of VEGF and VEGFR2 in both groups declined(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).The treatment in both groups elevated the levels of CD4+and CD4+/CD8+and lowered the level of CD8+(P＜0.05),and the changes in the observation group were higher than those in the control group(P＜0.05).Conclusion Jinrong Granules can significantly alleviate oxidative stress,improve the immune function and quality of life,and regulate the levels of angiogenesis-related factors and tumor markers in the TNBC patients undergoing neoad-juvant chemotherapy,being worthy of promotion.
Jinrong GranulesTriple-Negative Breast CancerNeoadjuvant Chemotherapy
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