Clinical Efficacy of Bushen Huoxue Tang on the Treatment of Premature Ovarian Insufficiency and Its Influence on Immune Factors
Objective To explore the clinical efficacy of Bushen Huoxue Tang in the treatment of patients with premature ovarian insufficiency(POI)and its influence on immune factors.Methods A total of POI 80 patients admitted to Suzhou Municipal Hospital of Traditional Chinese Medicine from January 2020 to September 2022 were selected and di-vided into a control group and an observation group according to the random number table,with 40 cases in each group.The control group received routine treatment,while the observation group received Bushen Huoxue Tang on the basis of the con-trol group.After three consecutive menstrual cycles,the clinical efficacy,adverse reactions,TCM syndrome score before and after treatment,and Kupperman score,as well as the serum levels of follicle-stimulating hormone(FSH),luteinizing hor-mone(LH),and Estrogen(E2),ovarian volume,antral follicle count(AFC),and peripheral blood cell immunity(CD4+,CD8+,and CD4+/CD8+)levels were observed and compared between the two groups.Result After treatment,the total effective rate of 92.5％(37/40)in the observation group was significantly higher than 75.0％(30/40)in the control group,and the difference was statistically significant(P＜0.05).After treatment,TCM syndrome scores and Kupperman scores of the two groups were significantly reduced(P＜0.05),and the TCM syndrome scores and Kupperman scores in the observation group were significantly lower than those in the control group(P＜0.05).After treatment,serum FSH and LH levels in both groups were significantly decreased,and E2 levels were significantly increased(P＜0.05),and the serum FSH and LH levels in the observation group were significantly lower than those in the control group,and E2 levels were sig-nificantly higher than those in the control group(P＜0.05).After treatment,the ovarian volume and AFC in both groups were higher than before treatment(P＜0.05),and the ovarian volume and AFC in the observation group were significantly higher than those in the control group(P＜0.05).After treatment,CD4+and CD4+/CD8+were higher,and CD8+was lower(P＜0.05).The CD4+and CD4+/CD8+levels in the observation group were significantly higher than those in the control group(P＜0.05),while CD8+levels were significantly lower than those in the control group(P＜0.05).During the treatment,neither group of patients experienced any serious adverse reactions.Conclusion Bushen Huoxue Tang can effectively alleviate the clinical symptoms of POI patients,regulate hormone levels in the body,promote follicular develop-ment,improve ovarian function,and enhance clinical efficacy.Its mechanism may be related to its ability to regulate the au-toimmune level of POI patients,and this plan is highly safe and is worth promoting.
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