Effect of Jiawei Zhenwu Decoction on Chronic Heart Failure Patients with Slow Ar-rhythmia and Its Effect on Hemodynamics
Objective To study the effect of Jiawei Zhenwu Decoction on chronic heart failure patients with slow arrhythmia and its effect on hemodynamics.Methods From January 2019 to January 2022,80 chronic heart failure pa-tients with slow arrhythmia were selected and divided into a control group and study group according to the random number table,with 40 cases in each group.The control group was treated with conventional western medicine,and the study group was treated with Jiawei Zhenwu Decoction on the basis of the control group.Patients in both groups were treated continu-ously for six weeks.After treatment,the clinical efficacy and adverse reactions of the two groups were compared,and the cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),and heart rate],hemodynamic indexes[cardiac output(CO)and cardiac output index(CI)],N-terminal pro-B-type natri-uretic peptide(NT-proBNP),matrix metalloproteinase-9(MMP-9),and endothelin-1(ET-1)levels were compared between the two groups before and after treatment.Results After treatment,the total clinical effective rate of 90.00％(36/40)in the study group was higher than that of 70.00％(28/40)in the control group,with statistical significance(P＜0.05).After treatment,LVEDD decreased,and LVEF and heart rate increased(P＜0.05).LVEDD in the study group was lower than that in the control group,and LVEF and heart rate in the study group were higher than those in the control group(P＜0.05).After treatment,the CO and CI of the two groups were higher than those before treatment(P＜0.05),and the CO and CI in the study group were higher than those in the control group(P＜0.05).After treatment,the levels of NT-proBNP,MMP-9,and ET-1 in both groups were lower than those before treatment(P＜0.05),and the levels of NT-proBNP,MMP-9,and ET-1 in the study group were lower than those in the control group(P＜0.05).During the treat-ment,the total incidence of adverse reactions in the control group was 17.50％(7/40).Compared with 15.00％(6/40)in the study group,there was no significant difference(x2=0.092,P=0.762).Conclusion Jiawei Zhenwu Decoction is ef-fective in treating chronic heart failure patients with slow arrhythmia,which can effectively improve cardiac function and regulate hemodynamics.It is worthy of clinical application.
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