Meta-analysis of the Effect of Modified Guipi Decoction on Blood Pressure,Nega-tive Psychology and Quality of Life in Elderly Patients with Hypertension and De-pression
Objective To systematically evaluate the impact of modified Guipi Decoction on elderly patients with hypertension and depression and its impact on patients'quality of life by using evidence-based medicine system assess-ment method and relying on scientific statistical method Meta-analysis.Methods A detailed search was conducted in the Chinese Medical Journal Full-text Database,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Platform,VIP(VIP Information),ClinicalKey,Wiley Online Library,Cochrane Library,PubMed(NCBI Foreign Medical Database),Karger Medical Electronic Journal,Embase,Elsevier,the Lancet,NEJM,JAMA,BMJ,and SinoMed databases by computer,and randomized controlled trials(RCTs)of Guipi Decoction on the treatment of elderly hypertension combined with depression were included.The scope of literature retrieval was from the establishment of the database to January 2023.Zotero literature management tool was used to process the retrieved literature.The Cochrane risk-of-bias tool and modi-fied Jadad scale were used to evaluate the quality of the literature,and data analysis was conducted using Review Manager 5.4 software.Results The meta-analysis included a total of 13 studies with 1,364 patients.The results showed that the treatment significantly reduced systolic blood pressure(WMD=-12.13,95%CI[-13.51,-10.75],P<0.000 01),di-astolic blood pressure(WMD=-8.53,95%CI[-10.40,-6.66],P<0.000 01),Hamilton Depression Scale score(WMD=-4.79,95%CI[-6.10,-3.49],P<0.000 01),quality of life evaluation scale score(WMD=-12.12,95%CI[7.31,16.94],P<0.000 01),and self-rating depression scale score(WMD=-6.07,95%CI[-7.35,-4.78],P<0.000 01)as compared to the control groups.Conclusion The treatment with modified Guipi Decoction can achieve a significant effect in lowering blood pressure levels among elderly individuals with hypertension,and it also shows remarka-ble efficacy in improving their depressive symptoms and enhancing their quality of life.