首页|归脾汤加减治疗老年高血压病合并抑郁症患者对血压、负性心理及生活质量影响的Meta分析

归脾汤加减治疗老年高血压病合并抑郁症患者对血压、负性心理及生活质量影响的Meta分析

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目的 通过使用循证医学体系评价方法,并以科学的统计方法Meta分析为依据,系统评价归脾汤加减治疗老年性高血压合并抑郁症及其对生活质量的影响.方法 计算机检索中华医学期刊全文数据库、中国知网(CNKI)、万方数据知识平台、维普网(维普资讯VIP)、ClinicalKey、Wiley Online Library、Cochrane图书馆、PubMed 数据库(NCBI 外文医学数据库)、Karger 医学电子期刊、Embase、Elsevier、The Lancet、NEJM、JAMA、BMJ、SinoMed数据库,纳入归脾汤加减治疗老年性高血压合并抑郁症的临床随机对照试验(Randomized controlled trial,RCT).文献检索的范围为数据库建立时间至2023年1月31日.使用Zotero文献管理工具对检出的文献进行处理;筛选出的文献通过Cochrane偏倚风险评估工具和改良Jadad评分法,进行文献质量评估与评价;结果 分析利用Review Manager 5.4软件完成.结果 共纳入13项,共1364例患者.Meta分析结果显示,治疗收缩压(WMD=-12.13,95%CI[-13.51,-10.75],P<0.000 01);舒张压(WMD=-8.53,95%CI[-10.40,-6.66],P<0.000 01);汉密尔顿抑郁量表评分(WMD=-4.79,95%CI[-6.10,-3.49],P<0.000 01);生命质量评价量表评分(WMD=-12.12,95%CI[7.31,16.94],P<0.000 01);抑郁自评量表评分(WMD=-6.07,95%CI[-7.35,-4.78],P<0.000 01)均明显优于对照组.结论 归脾汤加减治疗可以在老年人高血压水平方面达到降压效果,且在改善其抑郁症状并提高生活质量方面疗效显著.
Meta-analysis of the Effect of Modified Guipi Decoction on Blood Pressure,Nega-tive Psychology and Quality of Life in Elderly Patients with Hypertension and De-pression
Objective To systematically evaluate the impact of modified Guipi Decoction on elderly patients with hypertension and depression and its impact on patients'quality of life by using evidence-based medicine system assess-ment method and relying on scientific statistical method Meta-analysis.Methods A detailed search was conducted in the Chinese Medical Journal Full-text Database,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Platform,VIP(VIP Information),ClinicalKey,Wiley Online Library,Cochrane Library,PubMed(NCBI Foreign Medical Database),Karger Medical Electronic Journal,Embase,Elsevier,the Lancet,NEJM,JAMA,BMJ,and SinoMed databases by computer,and randomized controlled trials(RCTs)of Guipi Decoction on the treatment of elderly hypertension combined with depression were included.The scope of literature retrieval was from the establishment of the database to January 2023.Zotero literature management tool was used to process the retrieved literature.The Cochrane risk-of-bias tool and modi-fied Jadad scale were used to evaluate the quality of the literature,and data analysis was conducted using Review Manager 5.4 software.Results The meta-analysis included a total of 13 studies with 1,364 patients.The results showed that the treatment significantly reduced systolic blood pressure(WMD=-12.13,95%CI[-13.51,-10.75],P<0.000 01),di-astolic blood pressure(WMD=-8.53,95%CI[-10.40,-6.66],P<0.000 01),Hamilton Depression Scale score(WMD=-4.79,95%CI[-6.10,-3.49],P<0.000 01),quality of life evaluation scale score(WMD=-12.12,95%CI[7.31,16.94],P<0.000 01),and self-rating depression scale score(WMD=-6.07,95%CI[-7.35,-4.78],P<0.000 01)as compared to the control groups.Conclusion The treatment with modified Guipi Decoction can achieve a significant effect in lowering blood pressure levels among elderly individuals with hypertension,and it also shows remarka-ble efficacy in improving their depressive symptoms and enhancing their quality of life.

Guipi DecoctionElderly HypertensionDepressionRandomized Controlled TrialMeta-analysis

周凌风、牛增辉、付莹坤、崔美玉、雷燕、杨静

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中国中医科学院医学实验中心,北京 100700

中国中医科学院广安门医院,北京 100053

归脾汤 老年高血压 抑郁症 随机对照试验 Meta分析

国家自然科学基金

82074260

2024

世界中西医结合杂志
中华中医药学会

世界中西医结合杂志

CSTPCD
影响因子:1.053
ISSN:1673-6613
年,卷(期):2024.19(4)
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