摘要
目的 探讨失眠与高血压病共病的疾病特点及中医药治疗思路,筛选核心用药规律与处方配伍.方法 检索CNKI、Wanfang Data、VIP、SinoMed、PubMed数据库中使用中药复方治疗失眠合并高血压病的临床研究文献,将处方名称及组成药物录入Excel中,对药物的频次、类别、性味、归经进行统计,并使用R Studio(v4.2.2)进行层次聚类与关联规则分析.结果 共提取处方74个,中药133味.使用频次前5的中药分别为酸枣仁、白芍、甘草、茯苓、首乌藤,高频中药功效分类依次为补虚药、安神药、清热药、平肝息风药、活血化瘀药.药性以平、寒为主,药味以甘、苦、辛为主,主要归肝、心经.层次聚类得到5类方药,关联规则得到核心药物组合,包括酸枣仁、龙骨、牡蛎、首乌藤、知母、白芍、天麻、钩藤.结论 失眠与高血压病共病病位以肝、心为主,病性以阳热多见,治疗注重滋阴养血、清心平肝.用药补、降、开三法并举,主予补缓,兼顾清降,不忘通调,共同和畅气血阴阳.处方以调肝为核心,养肝、平肝、清肝之法共用,肝之体用同治.
Abstract
Objective To explore the disease characteristics of insomnia and hypertension comorbidity and the i-deas of traditional Chinese medicine(TCM)treatment,and to find the core medication rules and prescription compatibility.Methods The clinical research literature of Chinese herbal compound prescriptions for insomnia and hypertension was re-trieved from CNKI,Wanfang Data,VIP,SinoMed,and PubMed.The prescription names and constituent drugs were recorded in Excel,and statistical analysis was conducted on herbal frequency,category,property,flavor and channel tropism.R Stu-dio(v4.2.2)was used to perform cluster and association rule analysis.Results A total of 74 prescriptions with 133 Chi-nese herbs were extracted.The top 5 frequently used Chinese herbs were ZiziphiSpinosae Semen,Radix Paeoniae Alba,Gly-cyrrhizae Radix Et Rhizoma,Poria and PolygoniMultiflori Caulis.The high-frequency Chinese herbs were classified in the following order of efficacy categories:deficiency tonifying,tranquilizer,heat-clearing,liver calming,and blood-stasis acti-vating.The medicinal properties were mainly mild and cold,the medicinal flavors were mainly sweet,bitter and spicy,and the main meridians involved were the liver meridian and heart meridian.Five classes of prescriptions were obtained by hier-archical clustering,and the core herbal combinations were obtained by association rules,including ZiziphiSpinosae Semen,Dragon Bone,Ostreae Concha,PolygoniMultiflori Caulis,RhizomaAnemarrhee,Radix Paeoniae Alba,GastrodiaeRhizoma and RamulusUncariae Cum Uncis.Conclusion The comorbidity of insomnia and hypertension is primarily associated with the liver and heart,and the pathological nature often involves excess yang and heat.Treatment focuses on nourishing yin,nourishing blood,and clearing the heart while soothing the liver.The medication strategy combines tonifying,descending,and opening simultaneously,primarily emphasizing tonification and moderation together with clearing and reducing.The regulating and harmonizing aspect should not be neglected while nourishing yin and subduing yang,adjusting qi and blood.The prescription revolves around regulating the liver as the core,combining methods of nourishing,soothing,and clearing the liver,with the same treatment principles for the liver's constitution and function.
维普
万方数据