Data Mining-Based Research on Traditional Chinese Medicine Compound Treat-ment for Insomnia Combined with Hypertension
Objective To explore the disease characteristics of insomnia and hypertension comorbidity and the i-deas of traditional Chinese medicine(TCM)treatment,and to find the core medication rules and prescription compatibility.Methods The clinical research literature of Chinese herbal compound prescriptions for insomnia and hypertension was re-trieved from CNKI,Wanfang Data,VIP,SinoMed,and PubMed.The prescription names and constituent drugs were recorded in Excel,and statistical analysis was conducted on herbal frequency,category,property,flavor and channel tropism.R Stu-dio(v4.2.2)was used to perform cluster and association rule analysis.Results A total of 74 prescriptions with 133 Chi-nese herbs were extracted.The top 5 frequently used Chinese herbs were ZiziphiSpinosae Semen,Radix Paeoniae Alba,Gly-cyrrhizae Radix Et Rhizoma,Poria and PolygoniMultiflori Caulis.The high-frequency Chinese herbs were classified in the following order of efficacy categories:deficiency tonifying,tranquilizer,heat-clearing,liver calming,and blood-stasis acti-vating.The medicinal properties were mainly mild and cold,the medicinal flavors were mainly sweet,bitter and spicy,and the main meridians involved were the liver meridian and heart meridian.Five classes of prescriptions were obtained by hier-archical clustering,and the core herbal combinations were obtained by association rules,including ZiziphiSpinosae Semen,Dragon Bone,Ostreae Concha,PolygoniMultiflori Caulis,RhizomaAnemarrhee,Radix Paeoniae Alba,GastrodiaeRhizoma and RamulusUncariae Cum Uncis.Conclusion The comorbidity of insomnia and hypertension is primarily associated with the liver and heart,and the pathological nature often involves excess yang and heat.Treatment focuses on nourishing yin,nourishing blood,and clearing the heart while soothing the liver.The medication strategy combines tonifying,descending,and opening simultaneously,primarily emphasizing tonification and moderation together with clearing and reducing.The regulating and harmonizing aspect should not be neglected while nourishing yin and subduing yang,adjusting qi and blood.The prescription revolves around regulating the liver as the core,combining methods of nourishing,soothing,and clearing the liver,with the same treatment principles for the liver's constitution and function.
Data MiningInsomniaHypertensionChinese Herbal Compound PrescriptionsMedication Rules
万方数据
维普
