Efficacy of Ziyin Shugan Granule Combined with Auricular-Plaster Therapy for Girls with Precocious Puberty and Its Influence on Sex Hormones and Gonad Vol-ume
Objective To observe the effect of Ziyin Shugan Granule combined with auricular-plaster therapy on girls with precocious puberty and its influence on sex hormones and gonad volume.Methods A total of 98 girls with pre-cocious puberty admitted to the First People's Hospital of Jingzhou from January 2021 to October 2022 were selected and divided into a control group and an observation group by random number table,with 49 in each group.The girls in the con-trol group were treated with leuprorelin,while those in the observation group received Ziyin Shugan Granule combined with auricular-plaster therapy for 3 months.The clinical efficacy,adverse reactions and traditional Chinese medicine(TCM)syndrome scores before and after treatment were compared between the groups.Sex hormones[serum progesterone(P),tes-tosterone(T),estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH),and prolactin(PRL)],breast nucleus index,uterine volume,ovarian volume,and bone age(BA)/chronological age(CA)ratio were also measured and compared between the two groups.Results After treatment,TCM syndrome scores for the two groups of children decreased compared with the conditions before treatment(P<0.05),and the observation group had lower scores than the control group(P<0.05).Serum levels of P,LH,FSH,E2,and PRL were down-regulated after treatment compared with those be-fore treatment(P<0.05),and the observation group exhibited lower levels compared with the control group(P<0.05).Changes in serum T level were not significant(P>0.05),and there was no difference between the two groups after treat-ment(P>0.05).Uterine volume,ovarian volume,breast nucleus index,and BA/CA ratio decreased in both groups com-pared with the conditions before treatment(P<0.05),with the observation group having greater reductions than the control group(P<0.05).The total clinical effective rate was 87.50%(42/48)in the observation group,higher than the 72.34%(34/47)in the control group(x2=6.247,P=0.012).No difference was observed in the incidence of adverse reactions between the two groups(x2=0.146,P=0.702).Conclusion Ziyin Shugan Granule combined with auricular-plaster therapy can regulate sex hormones,reduce gonad volume,inhibit the premature development of secondary sexual character-istics,and improve clinical efficacy.