Clinical Observation on Jiuwei Zhenxin Granules Combined with Flupentixol-Meli-tracen Tablets and Bifidobacterium Tetrad in the Treatment of Irritable Bowel Syn-drome
Objective To investigate the clinical efficacy of Jiuwei Zhenxin Granules combined with flupentixol-melitracen tablets and Bifidobacterium Tetrad in treating irritable bowel syndrome(IBS).Methods One hundred IBS pa-tients admitted to Xinyang Central Hospital from January 2020 to January 2021 were selected and divided into a control group(50 cases)and a study group(50 cases)using a random number table method.The control group was given flupentixol-melitracen tablets plus Bifidobacterium Tetrad,while the study group was treated with Jiuwei Zhenxin Granules on the basis of the control group.Clinical efficacy,adverse reactions,and TCM syndrome scores before and after treatment were compared between the two groups.Additionally,rectal sensitivity(anal resting pressure,rectal perceptual threshold,abdomi-nal pain threshold,defecation threshold),neurotransmitters[5-hydroxytryptamine(5-HT),calcitonin gene-related pep-tide(CGRP),neuropeptide Y(NPY)],diamine oxidase,D-lactic acid,and endotoxin were measured and compared be-fore and after treatment.Results The total effective rate of the study group(98.00％,49/50)was higher than the control group(86.00％,43/50)(P＜0.05).After treatment,scores for symptoms such as loose stools,faint abdominal pain,fre-quent awakening,increased defecation frequency,dyspnea and reticence,palpitations,fatigue,reduced appetite,bloating,and pallor,along with indices of anal canal resting pressure,rectal perception threshold,abdominal pain threshold,defeca-tion threshold,and levels of 5-HT,CGRP,NPY,diamine oxidase,D-lactic acid,and endotoxin all showed improvement(all P＜0.05),with the study group exhibiting more improvement than the control group(P＜0.05).The incidence of ad-verse reactions during treatment was lower in the study group(1.44％,2/50)than the control group(16.00％,8/50)(x2=4.001,P=0.041).Conclusion Jiuwei Zhenxin Granules combined with flupentixol-melitracen tablets and Bifidobacterium Tetrad can alleviate the clinical symptoms of IBS patients,reduce TCM syndrome scores,and restore neuro-transmitter levels and intestinal barrier function,with significant efficacy and high safety.
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