Clinical Efficacy of Modified Shengmai Powder in the Treatment of Type 2 Diabetes Mellitus Patients with Acute Kidney Injury and Its Renal Protective Mechanism
Objective To observe the clinical efficacy of Modified Shengmai Powder in the treatment of type 2 di-abetes mellitus(T2DM)patients with acute kidney injury(AKI),and to explore its protective mechanism on renal function.Methods A total of 110 T2DM patients with AKI admitted to the Second Affiliated Hospital of Guizhou University of Tra-ditional Chinese Medicine from March 2021 to March 2023 were divided into a control group(treated with Western medi-cine,n=55)and an observation group(treated with Western medicine and modified Shengmai Powder,n=55)by random number table.After 4 weeks of treatment,clinical efficacy and traditional Chinese medicine(TCM)syndrome scores were compared between the two groups.Glucose metabolism indexes[fasting blood glucose(FBG),2-h postprandial blood glu-cose(2hPG),glycosylated hemoglobin(HbA1c)],renal function indexes[serum creatinine(Scr),blood urea nitrogen(BUN),endogenous creatinine clearance rate(Ccr),urinary albumin excretion rate(UAER),and urinary microalbumin(mALB)],kidney injury markers[serum cystatin C(CysC),urine neutrophil gelatinase-associated lipocalin(NGAL),kidney injury molecule-1(KIM-1)],and inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-alpha(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6),and interleukin-18(IL-18)]be-fore and after treatment were also detected and compared.Results After 1 week and 4 weeks of treatment,the TCM syn-drome scores of patients in both groups decreased(P＜0.05),with the observation group showing a more significant reduc-tion than the control group(P＜0.05).Blood glucose(FBG,2hPG)and HbA1c were reduced in both groups after treatment(P＜0.05),but there was no difference between the two groups(P＞0.05).Levels of BUN,Scr,UAER,and mALB in both groups decreased while level of Ccr increased compared with those before treatment(P＜0.05),with the observation group showing lower or higher levels than the control group(P＜0.05).Serum CysC,urine KIM-1,and NGAL in both groups were down-regulated compared with those before treatment(P＜0.05),and the observation group had lower levels than the control group(P＜0.05).Serum inflammatory factors(hs-CRP,TNF-α,IL-1β,IL-6,and IL-18)were re-duced after treatment in both groups,with the observation group showing lower levels compared with the control group(P＜0.05).The total effective rate in the observation group was 90.91％(50/55),higher than the 80.00％(44/55)in the control group(P＜0.05).No death was found in both groups,and there was no difference in the occurrence of adverse re-actions between the two groups during treatment(P＞0.05).Conclusion Modified Shengmai Powder can improve clinical symptoms,enhance clinical efficacy,and protect renal function in T2DM patients with AKI.Its mechanism may be related to the down-regulation of kidney injury and inflammatory factors.
Type 2 diabetes mellitusAcute kidney injuryShengmai PowderRenal functionInflammation
万方数据
维普
