Clinical Observation on Diankuang Mengxing Decoction in the Treatment of Patients with Ischemic Stroke Complicated by Mild Cognitive Impairment
Objective To observe the clinical efficacy of Diankuang Mengxing Decoction in the treatment of pa-tients with ischemic stroke complicated by mild cognitive impairment.Methods Seventy-eight patients with ischemic stroke and concurrent mild cognitive impairment admitted to the Seventh People's Hospital of Hebei Province and the Sec-ond Affiliated Hospital of Hebei College of Chinese Medicine from January 2020 to October 2021 were selected.They were randomized into a control group and an observation group by random number table,each with 39 cases.The control group was given standard treatment for ischemic stroke,while the observation group was treated Diankuang Mengxing Decoction in addition to the standard treatment.Two treatment courses were performed,four weeks as one course.The two groups were e-valuated for clinical efficacy and scored using the Montreal Cognitive Assessment(MoCA).Inflammatory markers[interleu-kin-6(IL-6),interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)],platelet-derived growth factor(PDGF),brain-derived neurotrophic factor(BDNF),plasma viscosity,and D-dimer(D-D)were analyzed before and after treat-ment.Results The total effective rate in the observation group(92.31％,36/39)was higher than the control group(74.36％,29/39)after treatment(P＜0.05).Post-treatment scores of visual networking and execution,attention,lan-guage and abstraction,delayed memory,and the total MoCA score were improved in both groups compared with the condi-tions before treatment(P＜0.05),with the observation group scoring notably higher than the control group(P＜0.05).IL-2 was increased while IL-6 and TNF-α were decreased after treatment in both groups(P＜0.05),and the observation group showed higher IL-2 and lower IL-6 and TNF-α than the control group(P＜0.05).After treatment,PDGF,plas-ma viscosity,and D-D were reduced,while BDNF was increased(P＜0.05),with the observation group having lower PDGF,plasma viscosity,and D-D,and higher BDNF when compared with the control group(P＜0.05).Conclusion Di-ankuang Mengxing Decoction is clinically valuable in improving cognitive function in patients with ischemic stroke compli-cated by mild cognitive impairment.
万方数据
维普
