Effect of Jiawei Shenqi Huazhuo Decoction Combined with High-Flux Hemodialysis on Oxidative Stress and Inflammatory Response in Patients with Chronic Renal Failure
Objective To explore the effect of Jiawei Shenqi Huazhuo Decoction combined with high-flux hemo-dialysis(HFHD)on oxidative stress and inflammatory response in patients with chronic kidney failure.Methods A total of 94 patients with chronic renal failure admitted to our hospital from April 2022 to April 2023 were selected and randomly di-vided into two groups:the HFHD group and the combination group,with 47 patients in each group.The HFHD group was treated with HFHD,while the combination group was treated with Jiawei Shenqi Huazhuo Decoction combined with HFHD.Both groups were treated for 4 consecutive weeks.Clinical efficacy was observed and compared between the two groups,in-cluding pre-and post-treatment traditional Chinese medicine(TCM)syndrome scores,renal function[blood urea nitrogen(BUN),and serum creatinine(Scr)],renal hemodynamics,immune function[CD4+,CD3+],oxidative stress[total an-tioxidant capacity(TAOC),and advanced oxidation protein products(AOPP)],and inflammatory response[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]levels.Results After treatment,the TCM syn-drome scores of both groups decreased compared to before treatment,with statistical significance(P＜0.05),and the com-bination group had significantly lower TCM syndrome scores than the HFHD group(P＜0.05).The renal function indica-tors BUN and SCr levels of both groups remarkably decreased after treatment compared to before treatment(P＜0.05),and the BUN and SCr levels of the combination group were significantly lower than those of the HFHD group(P＜0.05).The renal artery diameter and renal blood flow of both groups increased after treatment compared to before treatment,with statis-tical significance(P＜0.05);the renal artery diameter and renal blood flow of the combination group were significantly higher than those of the HFHD group(P＜0.05).The CD4+and CD3+levels of both groups significantly increased after treatment compared to before treatment(P＜0.05);the CD4+and CD3+levels of the combination group were significantly higher than those of the HFHD group(P＜0.05).The TAOC,AOPP,hs-CRP,and TNF-α levels of both groups signifi-cantly decreased after treatment compared to before treatment(P＜0.05);moreover,the levels of these indicators of the combination group were significantly lower than those of the HFHD group(P＜0.05).The overall clinical effective rate of the combination group after treatment was 93.62％(44/47),substantially higher than that of the HFHD group at 78.72％(37/47),with statistical significance(P＜0.05).Conclusion Using a combination of Jiawei Shenqi Huazhuo Decoction and HFHD for the treatment of chronic renal failure patients can reduce the severity of TCM syndromes,improve renal function,renal hemodynamics,and immune function,alleviate oxidative stress damage and inflammation,and achieve signif-icant therapeutic effect.
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维普
