Clinical Efficacy of Yushen Huoxue Prescription in the Treatment of Patients with Ovarian Endometriosis After Conservative Operation
Objective To evaluate the clinical efficacy of Yushen Huoxue Prescription in treating patients with o-varian endometriosis(EMs)after conservative operation.Methods A total of 64 patients who underwent conservative oper-ation for ovarian EMs of blood stasis at Shanghai Municipal Hospital of Traditional Chinese Medicine from 2019 to 2021 were enrolled.Based on patient preference,they were divided into an experimental group that received leuprolide acetate combined with Yushen Huoxue Prescription and a control group that received only leuprolide acetate,with 32 in each group.The control group received the injection on the third day after operation,while the experimental group was given Yushen Huoxue Prescription on the basis of the control group for 6 menstrual cycles.The study observed and compared the two-year postoperative recurrence rate,volume of recurrent endometriotic cysts,Visual Analogue Scale(VAS)scores for dysmenorrhea,blood-stasis TCM syndrome scores,and serum levels of carbohydrate antigen 125(CA1 25),intercellular adhesion molecule-1(ICAM-1),matrix metallopeptidase 9(MMP-9),and vascular endothelial growth factor(VEGF),as well as adverse reactions.Results The two-year postoperative recurrence rate in the experimental group was lower than that in the control group(12.50％,4/32 vs 18.75％,6/32)(P＜0.05).Additionally,the volume of recurrent endo-metriotic cysts in the experimental group was reduced compared with that in the control group(P＜0.01).Both groups dis-played a reduction in VAS scores after treatment(P＜0.01),with the experimental group having lower scores than the con-trol group(P＜0.01).The blood-stasis TCM syndrome scores also decreased after treatment in both groups(P＜0.01),with the experimental group scoring lower than the control group(P＜0.01).Serum CA125,ICAM-1,MMP-9,and VEGF decreased in the experimental group after treatment(P＜0.01).While the control group showed a significant de-crease in CA1 25,ICAM-1,and MMP-9(P＜0.01),there was no significant change in VEGF(P＞0.05).Moreover,the levels of CA1 25,ICAM-1,MMP-9,and VEGF were lower in the experimental group than in the control group(P＜0.01).There were no abnormal findings in blood,urine,stool,liver,or kidney functions of either group during treatment.Conclusion Yushen Huoxue Prescription combined with leuprolide acetate demonstrated significantly better outcomes in preventing recurrence in patients with ovarian EMs after conservative operation than leuprolide acetate alone.The recurrent cysts were smaller,and there was a more substantial reduction in pain and blood-stasis TCM syndrome scores.The thera-peutic mechanism may be linked to improved adhesion,invasion,and angiogenesis of the endometrium.
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