Combined Treatment of Lung and Intestine:Clinical Efficacy and Effect on Gastro-intestinal Function in Sepsis Patients with Gastrointestinal Dysfunction
Objective To observe the clinical efficacy of combined treatment of lung and intestine and the effect of the combined treatment on gastrointestinal function in the sepsis patients with gastrointestinal dysfunction.Methods Eighty sepsis patients with gastrointestinal dysfunction admitted to the Intensive Care Unit of Changshu Hospital of Tradi-tional Chinese Medicine(New District H ospital)from October 2020 to February 2022 were selected and assigned into a control group and a study group according to the random number table method,with 40 patients in each group.The control group received conventional Western medicine treatment,and the study group received combined treatment of lung and in-testine on the basis of the therapy in the control group.All the patients were treated continuously for 7 days.The clinical ef-ficacy and safety were compared between the two groups.The TCM syndrome scores,gastrointestinal function,gastrointesti-nal hormones,and inflammatory mediators[procalcitonin(PCT),tumor necrosis factor-α(TNF-α),and interleukin-4(IL-4)]were determined before and after treatment.Results After treatment,the total response rate in the study group was 97.50％(39/40),which was higher than that(82.50％,33/40)in the control group(P＜0.05).After treatment,the scores of fever,polydipsia,abdominal distension,press pain,chest pain,shortness of breath,and halitosis or dry mouth de-creased in both groups,and the study group had lower scores than the control group(P＜0.05).The treatment in both groups decreased the intraperitoneal pressure,gastric residue,and GIF score and increased the intestinal sounds,and the study group showed more obvious changes than the control group(P＜0.05).After treatment,both groups showed elevated levels of motilin and vasoactive intestinal peptide and lowered gastrin level,and the study group had higher levels of motilin and vasoactive intestinal peptide and lower gastrin level than the control group(P＜0.05).The treatment in both groups lowered the levels of PCT and TNF-α and elevated the level of IL-4,and the study group had lower levels of PCT and TNF-α and higher IL-4 level than the control group after treatment(P＜0.05).Neither group reported adverse reactions during the treatment period,and the stool,urine,and blood routines were normal.Conclusion The combined treatment of lung and intestine can regulate gastrointestinal function in the sepsis patients with gastrointestinal dysfunction,demonstra-ting definite therapeutic effect.
Combined Treatment of Lung and IntestineGastrointestinal Dysfunction in SepsisGastrointestinal FunctionGastrointestinal HormoneInflammatory Mediator
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