Clinical Efficacy of Modified Liujunzi Decoction for Colon Cancer Patients Undergo-ing Postoperative Chemotherapy and Its Impact on Immune Function
Objective To explore the clinical efficacy of Liujunzi Decoction for colon cancer patients undergoing postoperative chemotherapy and its impact on immune function.Methods A total of 136 colon cancer patients undergoing postoperative chemotherapy in the Department of Oncology,Tangshan Hospital of Traditional Chinese Medicine from Janu-ary 2020 to January 2022 were selected and divided into a control group and an observation group by random number table,with 68 in each group.The control group received the mFOLFOX6 regimen,while the observation group received modified Liujunzi Decoction on the basis of the control group.One course of treatment included 12 cycles,with two weeks as one cy-cle.The clinical efficacy,quality of life,adverse reactions,TCM evidence scores,KPS scores,and immune function were compared between the two groups before and after treatment.Results The KPS scores of the two groups increased after treatment(P＜0.05),and the observation group had higher scores than the control group(P＜0.05).The TCM symptom scores decreased in both groups(P＜0.05),and the observation group had lower scores than the control group(P＜0.05).The Th17 and Th17/Treg ratio were elevated in both groups after treatment(P＜0.05),with the observation group having more elevation or reduction than in the control group(P＜0.05).The improvement rate of quality of life in the observation group was 79.69％(49/64),higher than the 53.22％(34/62)in the control group(P＜0.05).The total effective rate of the observation group was 95.31％(61/64),higher than the 88.71(55/62)of the control group(P＜0.05).During treat-ment,the incidence of adverse reactions in the observation group was 10.94％(7/64),lower than the 24.19％(15/62)in the control group(P＜0.05).Conclusion Modified Liujunzi Decoction positively impacts the recovery of gastrointestinal function in colon cancer patients undergoing postoperative chemotherapy,regulating the balance of Th17/Treg cells,and re-ducing the adverse reactions and toxic side effects due to postoperative chemotherapy.This mechanism may be related to its ability to regulate the balance of Th17/Treg cells and improve the patient's immune function.
Modified Liujunzi DecoctionColon cancerChemotherapyGastrointestinal functionBalance of Th 17/Treg cellsImmune function
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维普
