Medication Rules and Mechanism of Professor Liu Qiquan in Treatment of Chronic Atrophic Gastritis Based on Data Mining
Objective To explore the medication rules and core drug mechanisms of Professor Liu Qiquan in the treatment of chronic atrophic gastritis(CAG)based on the ancient and modern medical case cloud platform and network pharmacology methods and provide objective evidence for the treatment of CAG.Methods The outpatient prescriptions of Professor Liu Qiquan for treating CAG were collected.The relevant medication rules were excavated through the ancient and modern medical case cloud platform.The active ingredients of core drug combinations and potential targets of CAG were an-alyzed via network pharmacology methods.Results A total of 635 medical cases were included,involving 176 drugs,with 42 used more than 110 times,mainly for clearing heat,regulating qi,tonifying deficiency,activating blood,and resolving stasis.In combination of high-frequency drugs,association rules,and cluster analysis,the core drug combination for trea-ting CAG was determined to be Taraxaci Herba,Corydalis Rhizoma,Angelicae Sinensis Radix,Poria,Curcumae Radix,Aco-ri Tatarinowii Rhizoma,Paeoniae Radix Alba,Curcumae Rhizoma,and Cyperi Rhizoma.Network pharmacology analysis showed that active ingredients such as 8-isopentenyl kaempferol,kaempferol,and β-sitosterol in the core drug combina-tion acted on core targets such as protein kinase B1(AKT 1),tumor suppressor p53(TP 53),interalleukin(IL)-6,and tumor necrosis factor(TNF).The potential targets of the core drug combination for treating CAG were mainly enriched in 66 cellular components,99 molecular functions,and 683 biological processes.The main biological pathways included cancer pathway,IL-17 signaling path way,TNF signaling pathway,phosphoinositide 3-kinase/protein kinase B(PI3K/Akt)sig-naling pathway,and p53 signaling pathway.Conclusion The data mining method effectively reflects the medication rules of Professor Liu Qiquan in the treatment of CAG,focusing on the core pathogenesis of"liver depression,heat-toxin,and blood stasis",prioritizing liver regulation,detoxification,promoting blood circulation,and tonifying deficiency simultaneous-ly.It also preliminarily revealed the multi-target mechanism of Professor Liu Qiquan in the treatment of CAG,providing references for clinical application.
Experience of Famous DoctorsChronic Atrophic GastritisLiu QiquanData MiningMedication RulesNetwork Pharmacology
万方数据
维普
