Therapeutic Effect of Fumai Yixin Formula on Rheumatic Heart Valve Disease and Its Impact on Heart Function,Matrix Metalloproteinase-9,and N-terminal Pro-brain Natriuretic Peptide Levels in Patients with Rheumatic Heart Valve Disease
Objective To explore the therapeutic effect of Fumai Yixin Formula in the adjuvant treatment of rheu-matic heart valve disease and its effects on patient heart function,serum matrix metalloproteinase-9(MMP-9)levels,and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels.Methods A total of 88 patients with rheumatic heart valve disease admitted to the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from February 2021 to February 2022 were selected as the research subjects.The patients were divided into a control group and an obser-vation group using a random number table method,with 44 cases in each group.Both groups of patients underwent mitral valve replacement surgery,receiving routine Western medicine treatment based on their condition after surgery.The obser-vation group received a combination of Fumai Yixin Formula and conventional Western medicine treatment for 4 weeks after surgery.Changes in the traditional Chinese medicine syndrome scores,MMP-9,NT-proBNP levels,the cardiac function indicators(minute cardiac output,stroke output,heart index,left ventricular ejection fraction),and the quality of life scores(social and physical limitations,symptoms,emotions)between two groups of patients after 4 weeks of treatment were ob-served and compared.Clinical efficacy after 4 weeks of treatment and the safety of the treatment plans for both groups of patients was evaluated.Results After treatment,the scores of palpitations,fatigue,shortness of breath,night or spontane-ous sweating,restlessness,insomnia,and multiple dreams in both groups of patients were decreased compared to before treatment,and the difference was statistically significant(P<0.05);the scores of the observation group was lower than those of the control group,with a statistically significant difference(P<0.05).The serum levels of MMP-9 and NT-proBNP in both groups of patients were reduced compared to before treatment,and the difference was statistically significant(P<0.05);the observation group was significantly lower than the control group,with a statistically significant difference(P<0.05).The minute cardiac output,stroke output,cardiac index,and the left ventricular ejection fraction of the two groups of patients were increased compared to before treatment,and the difference was statistically significant(P<0.05);the observation group was higher than the control group,with a statistically significant difference(P<0.05).The social and physical limitations,symptoms,and emotional scores of the two groups of patients were reduced compared to before treatment,and the difference was statistically significant(P<0.05);the observation group was lower than the control group,with a statistically significant difference(P<0.05).The total effective rate of the observation group was 95.45%(42/44),which was significantly higher than that of the control group at 79.55%(35/44),and the difference was statisti-cally significant(P<0.05).Both groups of patients showed no abnormalities in liver and kidney function or blood routine before and after treatment,and there were no significant adverse reactions to medication after surgery.Conclusion Fumai Yixin Formula assisted mitral valve replacement surgery for rheumatic heart valve disease can reduce MMP-9 and NT-proBNP levels to help improve patient heart function,protect the myocardium,and quickly alleviate clinical symptoms,which improves the quality of life.
Rheumatic Heart Valve DiseaseFumai Yixin FormulaMitral Valve Replacement SurgeryMatrix Metalloproteinase-9N-terminal Pro-brain Natriuretic PeptideHeart FunctionQuality of Life