Efficacy of Modified Guizhi Fuling Pills in Treating Patients with Chronic Prostatitis and Its Mechanism of Inflammatory Regulation
Objective To investigate the efficacy of modified Guizhi Fuling Pills in the treatment of patients with chronic prostatitis(CP)and its mechanism of inflammatory regulation.Methods A total of 122 patients with CP admitted to Henan Province Hospital of TCM from January 2022 to January 2023 were selected and randomly divided into a control group and an observation group by computer,with 61 patients in each group.The control group was treated with convention-al Western medicine,while the observation group was treated with modified Guizhi Fuling Pills for eight weeks on the basis of the control group.The traditional Chinese medicine(TCM)syndrome score and CP symptom index(NIH-CPSI)were e-valuated before and after treatment,and the urodynamic parameters[maximum urinary flow rate(Qmax),average urinary flow rate(Qave),and residual urine volume(RUV)]were measured.The levels of inflammatory factors[interleukin-1β (IL-1β),interleukin-6(IL-6),and tumor necrosis factor α(TNF-α)]in expressed prostatic secretions(EPS)were detected.The clinical efficacy,safety,and recurrence rate after three months between the two groups were compared.Re-sults After treatment,the TCM syndrome and NIH-CPSI scores in the two groups decreased,and the differences were statistically significant(P＜0.05);compared with those in the control group,the NIH-CPSI and TCM scores in the obser-vation group were lower(P＜0.05).After treatment,the Qmax and Qave increased,and RUV decreased in the two groups(P＜0.05);compared with the control group,the observation group showed a more significant increase in Qmax and Qave and a more significant decrease in RUV(P＜0.05).After treatment,the levels of IL-1β,IL-6,and TNF-α in the two groups decreased(P＜0.05);compared with those in the control group,the levels of IL-1β,IL-6,and TNF-α in the observation group were lower(P＜0.05).After treatment,the clinical control rate and total effective rate of the observation group were 68.85％(42/61)and 91.80％(56/61),respectively,which were significantly higher than 47.54％(29/61)and 75.41％(46/61)of the control group(P＜0.05).During the treatment,neither group of patients experienced any sig-nificant adverse reactions,and there were no significant abnormal changes in liver and kidney function and three routine tests before and after treatment.During follow-up,there were three recurrence cases in the observation group(7.14％)and seven recurrence cases in the control group(24.14％).The short-term recurrence rate in the observation group was significantly lower than that in the control group(x2=9.701,P=0.002).Conclusion Modified Guizhi Fuling Pills have definite short-term efficacy on CP,which can improve clinical symptoms and urodynamics and reduce recurrence rate,and its mechanism may be related to the inflammatory regulation effect.
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