Objective To investigate the efficacy of modified Guizhi Fuling Pills in the treatment of patients with chronic prostatitis(CP)and its mechanism of inflammatory regulation.Methods A total of 122 patients with CP admitted to Henan Province Hospital of TCM from January 2022 to January 2023 were selected and randomly divided into a control group and an observation group by computer,with 61 patients in each group.The control group was treated with convention-al Western medicine,while the observation group was treated with modified Guizhi Fuling Pills for eight weeks on the basis of the control group.The traditional Chinese medicine(TCM)syndrome score and CP symptom index(NIH-CPSI)were e-valuated before and after treatment,and the urodynamic parameters[maximum urinary flow rate(Qmax),average urinary flow rate(Qave),and residual urine volume(RUV)]were measured.The levels of inflammatory factors[interleukin-1β (IL-1β),interleukin-6(IL-6),and tumor necrosis factor α(TNF-α)]in expressed prostatic secretions(EPS)were detected.The clinical efficacy,safety,and recurrence rate after three months between the two groups were compared.Re-sults After treatment,the TCM syndrome and NIH-CPSI scores in the two groups decreased,and the differences were statistically significant(P＜0.05);compared with those in the control group,the NIH-CPSI and TCM scores in the obser-vation group were lower(P＜0.05).After treatment,the Qmax and Qave increased,and RUV decreased in the two groups(P＜0.05);compared with the control group,the observation group showed a more significant increase in Qmax and Qave and a more significant decrease in RUV(P＜0.05).After treatment,the levels of IL-1β,IL-6,and TNF-α in the two groups decreased(P＜0.05);compared with those in the control group,the levels of IL-1β,IL-6,and TNF-α in the observation group were lower(P＜0.05).After treatment,the clinical control rate and total effective rate of the observation group were 68.85％(42/61)and 91.80％(56/61),respectively,which were significantly higher than 47.54％(29/61)and 75.41％(46/61)of the control group(P＜0.05).During the treatment,neither group of patients experienced any sig-nificant adverse reactions,and there were no significant abnormal changes in liver and kidney function and three routine tests before and after treatment.During follow-up,there were three recurrence cases in the observation group(7.14％)and seven recurrence cases in the control group(24.14％).The short-term recurrence rate in the observation group was significantly lower than that in the control group(x2=9.701,P=0.002).Conclusion Modified Guizhi Fuling Pills have definite short-term efficacy on CP,which can improve clinical symptoms and urodynamics and reduce recurrence rate,and its mechanism may be related to the inflammatory regulation effect.
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