Effects of Shenqi Yixin Decoction on Cardiac Function and NT-proBNP Level in Patients with Heart Failure Combined with Diuretic Resistance
Objective To investigate the therapeutic effect of modified Shenqi Yixin Decoction in patients with heart failure combined with diuretic resistance.Methods A total of 100 patients with heart failure combined with diuretic resistance admitted to the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from December 2021 to December 2022 were selected as the study objects and were divided into control group and experimental group according to random number table method,with 50 cases in each group.The control group was given conventional treatment,and the ex-perimental group was given Shenqi Yixin Decoction based on the control group.Both groups were treated for 4 weeks with two weeks as a course of treatment.Compare two groups before and after treatment in patients with cardiac function index,left ventricular end-diastolic diameter(LVDD),and left atrial diameter(LAD).Left ventricular ejection fraction(LVEF),serum indicators[N-terminal pro-brain natriuretic peptide(NT-proBNP),cardiac troponin T(CTnT),creatine phos-phate(creatine)kinase isoenzyme(Ck-MB)],and TCM syndrome score were calculated.In addition,the clinical efficacy and adverse reactions of the two groups were compared.Results After treatment,LVDD and LAD levels of cardiac func-tion in both groups were lower than before treatment,and LVEF levels were higher than before treatment,with statistical significance(P＜0.05).LVDD and LAD levels in experimental groups were lower than those in the control group,and the LVEF level was higher than that in the control group,the differences were statistically significant(P＜0.05).After treat-ment,the levels of NT-proBNP,CTnT,and Ck-MB in both groups were lower than before treatment,the difference was statistically significant(P＜0.05).The experimental group was lower than the control group,and the difference was statisti-cally significant(P＜0.05).After treatment,the scores of palpitation,shortness of breath,asthma,and chest tightness in both groups were lower than before treatment,with statistical significance(P＞0.05).The experimental group was lower than the control group,and the difference was statistically significant(P＜0.05).After treatment,the total effective rate of the experimental group was 96.00％(48/50),higher than that of the control group 72.00％(36/50),and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shenqi Yixin Decoction can significantly improve cardiac function and relieve clinical symptoms in patients with heart failure combined with diuretic resistance.
Heart FailureDiuretic ResistanceShenqi Yixin DecoctionTraditional Chinese Medicine Syndrome Points
万方数据
维普
