Clinical Efficacy of Huatan Xiaoyu Decoction Combined with Ethinylestradiol Cyproterone Tablets in Treating Patients with Polycystic Ovary Syndrome and Its Impact on Pregnancy
Objective To observe the therapeutic effect of Huatan Xiaoyu Decoction combined with ethinylestra-diol-cyproterone on patients with polycystic ovary syndrome(PCOS)and its impact on pregnancy.Methods Eighty P-COS patients who visited the Reproductive Medicine Center and Gynecology Department of Maternal and Child Health Hos-pital in Zaozhuang,Shandong Province,from June 2020 to June 2021 were selected as the research subjects.The patients were randomly divided into a control group and an observation group,with 40 patients in each group.The control group was treated with ethinylestradiol-cyproterone,while the observation group was treated with Huatan Xiaoyu Decoction combined with ethinylestradiol-cyproterone.Both groups were treated for 3 months.The traditional Chinese medicine(TCM)syn-drome score,serum hormone levels[luteinizing hormone(LH),follicle-stimulating hormone(FSH),testosterone(T),es-tradiol(E2)],ovarian volume,number of follicles,endometrial thickness(EM),resistance index(RI),and spiral artery pulsatility index(PI)were observed and compared before and after treatment between the two groups.Pregnancy outcomes were also compared between the two groups.Results After treatment,the TCM syndrome scores in both groups were sig-nificantly lower than before treatment,with a statistically significant difference(P＜0.05);the TCM syndrome scores in the observation group were significantly lower than those in the control group,with a statistically significant difference(P＜0.05).After treatment,serum hormone levels of E2,LH,and T in both groups were significantly lower,while FSH levels were higher than before treatment,with a statistically significant difference(P＜0.05).The serum hormone levels of E2,LH,and T in the observation group were significantly lower,while the FSH levels were significantly higher than those in the control group,with a statistically significant difference(P＜0.05).After treatment,ovarian volume and follicle number in both groups were significantly lower than before treatment,with a statistically significant difference(P＜0.05).The ovarian volume and follicle number in the observation group were significantly lower than those in the control group,with a statisti-cally significant difference(P＜0.05).After treatment,the EM values in both groups were higher,while PI and RI values were lower than before treatment,with a statistically significant difference(P＜0.05).The EM values in the observation group were significantly higher,while the PI and RI values were significantly lower than those in the control group,with a statistically significant difference(P＜0.05).After treatment,the pregnancy rate(71.05％,27/38),the ovulation rate(89.47％,34/38),and the birth rate(57.59％,22/38)in the observation group were significantly higher than those in the control group(51.36％,19/37;75.68％,28/37;24.32％,9/37).The early abortion rate(13.16％,5/38)was significant-ly lower than that in the control group(27.02％,10/37),with a statistically significant difference(P＜0.05).Conclusion The application of Huatan Xiaoyu Decoction can effectively alleviate the clinical symptoms of PCOS patients,improve ovari-an abnormalities,change polycystic conditions,regulate hormone levels and uterine receptivity,promote ovulation and preg-nancy,and improve the pregnancy rate.
万方数据
维普
