Evidence-Based Study and Clinical Validation of External Application of Chinese Medicines in Treating Chronic Pelvic Pain Caused by Sequelae of Pelvic Inflammato-ry Diseases
Objective To obtain clinician's recommendation of the Chinese medicines for the external treatment of chronic pelvic pain caused by the sequelae of pelvic inflammatory diseases(SPID-CPP).Methods Two rounds of ex-pert questionnaire surveys(Delphi method)were conducted to obtain the clinical questions concerned most by clinicians for the sequelae of pelvic inflammatory diseases and the importance points were scored to obtain clinical questions.Systematic reviews and randomized controlled trials were included by literature search,and the bias analysis was performed to obtain the evidence.The final recommendations were obtained after another round of questionnaire survey and verified by multi-center clinical trials.Results The active participation,opinion concentration,and authority coefficient of experts in the three rounds of surveys were high,which indicated high credibility of the results.Among the surveyed clinicians,91.11%strongly recommend Chinese patent medicines for clearing heat and drying dampness as well as resolving stasis and relie-ving pain for external treatment of SPID-CPP patients with the syndrome of dampness-heat combined with stasis.The clinical trials showed that the total response rate of retention enema of Chinese medicines for clearing heat and drying dampness as well as resolving stasis and relieving pain was 87.22%in the treatment of SPID-CPP.Conclusion Clini-cians paid high attention to the external application of Chinese medicines for treating SPID-CPP and preferred the use of Chinese patent medicines,with the strongest recommendation of enema for resolving stasis and dissipating mass for treating SPID-CPP patients with the syndrome of dampness-heat combined with stasis.For the patients with the syndrome above,the retention enema of Chinese medicines for clearing heat and removing dampness as well as resolving stasis and relieving pain has high a response rate.
Delphi MethodSequelae of Pelvic Inflammatory DiseaseChronic Pelvic PainExternal Treatment