Clinical Observation of Xiaoke Ointment on Type 2 Diabetes Mellitus with Kidney-Yin Deficiency in Hakka People in Eastern Guangdong
Objective To explore the clinical efficacy of the traditional Chinese medicine formula,namely Xiaoke Ointment on type 2 diabetes mellitus(T2DM)with kidney-Yin deficiency in the Hakka people in Eastern Guangdong.Methods Seventy T2DM patients with kidney-Yin deficiency,who were all local Hakka people and were admitted to Meizhou People's Hospital from January 2021 to December 2022 were selected.They were randomly divided into experi-mental and control groups,with 35 patients in each group.The control group was given conventional blood glucose interven-tion(insulin preparation treatment),and the experimental group was further given oral administration of traditional Chinese medicine formula.The course of treatment was 60 days for both groups.This paper monitored and compared the changes in clinical symptoms,renal function[blood urea nitrogen(BUN)and serum creatinine(Scr)],blood lipid[triglyceride(TC)and total cholesterol(TG)],blood glucose[glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG),and 2-hour postprandial blood glucose(PBG)],and occurrence of adverse reactions of patients in the two groups.Results After treat-ment,the total effective rate of the experimental group was 88.57％(31/35),higher than that of the control group 68.57％(24/35),and the difference was statistically significant(P＜0.05).The TCM syndrome scores in both groups were de-creased after treatment(P＜0.05),and the TCM syndrome scores in the experimental group were significantly lower than those in the control group(P＜0.05).After treatment,the BUN and Scr in both groups decreased(P＜0.05).In addition,the decrease in BUN and Scr was more obvious in the experimental group than that in the control group(P＜0.05).The levels of TG and TC decreased in both groups after treatment(P＜0.05),and the levels of TG and TC in the experimental groups were significantly lower than those in the control group(P＜0.05).During treatment,there was no significant differ-ence in the occurrence of adverse reactions between the two groups(P＞0.05).Conclusion Xiaoke Ointment can signifi-cantly improve the clinical symptoms of T2DM patients with kidney-Yin deficiency in the Hakka region in eastern Guang-dong,reduce disorders of lipid metabolism,and improve renal function,thus slowing down the occurrence and development of diabetic nephropathy(DN)and macroangiopathy.
Hakka Region in Eastern GuangdongType 2 Diabetes Mellitus with Kidney-Yin DeficiencyTradi-tional Chinese Medicine Xiaoke Ointment
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