Curative Effect of Yugeng Tongyu Decoction on Patients with Acute Myocardial In-farction and Its Influence on Hemodynamics and Myocardial Injury Markers
Objective To observe the curative effect of Yugeng Tongyu Decoction on patients with acute myocar-dial infarction(AMI)and its influence on hemodynamics and myocardial injury markers.Methods A total of 108 AMI pa-tients treated in Jiaozuo People's Hospital from May 2021 to May 2022 were selected as the study objects,and they were di-vided into a control group and a combined group according to a simple randomization method,with 54 cases in each group.The control group was given conventional symptomatic treatment,and the combined group was given Yugeng Tongyu Decoc-tion on the basis of the conventional symptomatic treatment.Both groups were treated for 14 days.The therapeutic effects of the two groups were compared,as well as inflammatory factors[tumor necrosis factor-nflammatory factors(tumor necroand IL-6)],hemodynamic indicators[cardiac output(CO),stroke volume(SV),and cardiac index(CI)],and markers of my-ocardial injury[cardiac troponin I(cTnI),heart type fatty acid binding protein(H-FABP),and creatine kinase isoenzyme(CK-MB)]after treatment of 14 days.The occurrence of outcome events in the two groups was analyzed after six months of follow-up.Results After treatment,the total effective rate of the combined group was 92.59％(50/54),higher than that of the control group 77.78％(42/54),and the difference was statistically significant(P＜0.05).After treatment,the inflammatory factors TNF-lammator,and IL-6 were decreased in the two groups(P＜0.05),and those in the combined group were lower than the control group(P＜0.05).After treatment,the hemodynamic indexes CO,SV,and CI in the two groups were higher(P＜0.05),and those in the combined group were higher than the control group(P＜0.05).After treatment,the myocardial injury markers cTnI,H-FABP,and CK-MB in the two groups were decreased(P＜0.05),and those in the combined group were lower than the control group(P＜0.05).During the 6-month follow-up,the incidence of stroke and re-hospitalization in the combined group was lower than that in the control group(P＜0.05).There was no significant difference in the incidence of nonfatal myocardial infarction,cardiovascular death,and revascularization between the two groups(P＞0.05).Conclusion Yugeng Tongyu Decoction is effective in the treatment of AMI,which can effec-tively inhibit inflammatory response,regulate hemodynamics,reduce the level of myocardial injury markers,and improve short-term prognosis.
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