Effect of Yiyuan Wentai Guchong Bushen Formula on Fetus Protection and Three Pregnancy Items of Patients with Threatened Abortion of Spleen and Kidney Defi-ciency Syndrome
Objective To explore the effect of Yiyuan Wentai Guchong Bushen Formula on fetus protection and endocrine hormones of patients with threatened abortion of spleen and kidney deficiency syndrome.Methods A total of 90 patients with threatened abortion admitted to the Obstetrics and Gynecology Department,Shenzhen Hospital of Traditional Chinese Medicine,from March 2021 to August 2022 were selected and divided into a study group(n=45)and a control group(n=45)based on a simple random number table method.The control group received routine treatment,while the study group received Yiyuan Wentai Guchong Bushen Formula on the basis of the control group.Both groups were treated for 14 days.The clinical efficacy,fetus protection effect,traditional Chinese medicine(TCM)syndrome score before and af-ter treatment,three pregnancy items[estradiol(E2),progesterone(P),and human chorionic gonadotropin(HCG)]levels,inflammatory factors[interleukin-2(IL-2)and interleukin-4(IL-4)],interferon-gamma(IFN-γ)level,and occur-rence of adverse reactions of the two groups were compared.Results The total effective rate of the study group(95.56％,43/45)was higher than that of the control group(82.22％,37/45),and the difference was statistically significant(P＜0.05).After treatment,the full-term pregnancy rate(82.22％,37/45)in the study group was higher than that in the control group(60.00％,27/45),and the preterm birth rate(13.33％,6/45)was lower than that in the control group(33.33％,15/45)(P＜0.05).After treatment,the scores of soreness and weakness of the waist and knees,abdominal pain,vaginal bleeding,loose stool,frequent nocturnal urination,poor abdominal distension,and sallow complexion in both groups were lower(P＜0.05).In addition,the TCM syndrome score of the study group was significantly lower than that of the control group(P＜0.05).After treatment,the levels of E2,P,and HCG in the two groups increased(P＜0.05),and levels in the study group were higher than those in the control group(P＜0.05).After treatment,the levels of serum IL-2 and IFN-γ in the two groups decreased,while the IL-4 level increased(P＜0.05).The levels of serum IL-2 and IFN-y in the study group were lower than those in the control group,and the IL-4 level in the study group was higher than that in the control group(P＜0.05).During treatment,no drug-related adverse reactions were observed in both groups.Conclusion On the ba-sis of routine intervention,adopting the Yiyuan Wentai Guchong Bushen Formula to treat threatened abortion of spleen and kidney deficiency syndrome can effectively alleviate clinical symptoms,regulate the levels of three pregnancy items and in-flammatory factors,and improve the treatment effect and fetus protection effect,with good safety.
NETL
NSTL
万方数据
