Clinical Efficacy of Modified Xuanbi Decoction by Oral Administration and External Washing Combined with Immunosuppressants in Treatment of Rheumatoid Arthritis Patients with Dampness-heat Obstruction Syndrome
Objective To investigate the clinical efficacy of modified Xuanbi Decoction by oral administration and external washing combined with immunosuppressants in treating patients with rheumatoid arthritis(RA)of dampness-heat obstruction syndrome.Methods From December 2018 to December 2022,102 RA patients with dampness-heat ob-struction syndrome treated at the Traditional Chinese Medicine Department of the Fuyang Fifth People's Hospital were se-lected and randomly divided into a control group and an experimental group according to a random single and even number method,with 51 patients in each group.The control group received immunosuppressant treatment for 3 months,while the experimental group received modified Xuanbi Decoction for oral administration and external washing in addition to the im-munosuppressants.The traditional Chinese medicine(TCM)symptom scores,Disease Activity Score of 28 joints(DAS28),Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),rheumatoid factor(RF),erythrocyte sedimen-tation rate(ESR),C-reactive protein(CRP)levels,clinical efficacy,and incidence of adverse reactions were compared be-tween the two groups before and after treatment.Results After treatment,the scores for limited flexion and extension,swelling,pain,and tenderness significantly decreased in both groups compared to those before treatment(P＜0.05),with the experimental group showing significantly lower TCM symptom scores than the control group(P＜0.05).DAS28 and WOMAC scores also significantly decreased in both groups compared to those before treatment(P＜0.05),with the experi-mental group scoring significantly lower than the control group(P＜0.05).RF,ESR,and CRP levels significantly de-creased in both groups compared to those before treatment(P＜0.05),with the experimental group showing significantly lower levels than the control group(P＜0.05).The total clinical efficacy rate in the experimental group was 97.78％(44/45),significantly higher than 82.98％(39/47)in the control group(P＜0.05).During the treatment period,the adverse reaction rate in the experimental group was 4.44％(2/45),significantly lower than 19.15％(9/47)in the control group(P＜0.05).Conclusion The combination of modified Xuanbi Decoction by oral administration and external washing and immunosuppressants in the treatment of RA with dampness-heat obstruction syndrome has synergistic and detoxifying effects,effectively alleviating symptoms,reducing disease activity,regulating inflammation,and lowering ESR.
Rheumatoid ArthritisImmunosuppressantModified Xuanbi DecoctionOral Administration and Ex-ternal WashingDampness-Heat Obstruction Syndrome
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