目的 探讨降气平喘固本汤联合穴位推拿治疗儿童支气管哮喘虚哮证的效果.方法 选取2018年11月-2023年6月期间北京中医医院怀柔医院收治的支气管哮喘虚哮证患儿102例作为研究对象,依据简单随机数字表法分为对照组和研究组,每组各51例.对照组采取常规西医治疗,研究组在对照组基础上采取降气平喘固本汤联合穴位推拿,共治疗4周.观察比较两组患儿临床疗效、不良反应发生率,治疗前后中医证候积分、肺功能[最大呼气峰流速(Peak expiratory flow,PEF)、第 1 秒用力呼气量(Forced expiratory volume in one second,FEV1)、用力肺活量(Forced vital capacity,FVC)]、免疫功能[白细胞介素-13(Interleukin-13,IL-13)、白细胞介素-12(Interleukin-12,IL-12)、白细胞介素-4(Interleukin-4,IL-4)、干扰素-γ(Interferon-gamma,IFN-γ)]水平.结果 治疗后研究组临床总有效率92.16％(47/51)明显高于对照组78.43％(40/51),差异有统计学意义(P＜0.05).治疗后两组患儿喉中哮鸣、形寒肢冷、咳痰无力、腰膝酸软、神疲乏力、声低气短分值均较治疗前降低,差异有统计学意义(P＜0.05);且研究组中医证候积分明显低于对照组,差异有统计学意义(P＜0.05).治疗后两组患儿肺功能PEF、FEV1、FVC水平均较治疗前升高,差异有统计学意义(P＜0.05);且研究组肺功能PEF、FEV1、FVC水平均明显高于对照组,差异有统计学意义(P＜0.05).治疗后两组患儿免疫功能IL-13、IL-4水平均较治疗前降低,IL-12、IFN-γ水平均较治疗前升高,差异有统计学意义(P＜0.05);且研究组免疫功能IL-13、IL-4水平均明显低于对照组,IL-12、IFN-γ水平均明显高于对照组,差异有统计学意义(P＜0.05).治疗期间,研究组不良反应发生率5.88％(3/51)与对照组3.92％(2/51)比较,差异无统计学意义(P＞0.05).结论 采取降气平喘固本汤联合穴位推拿治疗支气管哮喘虚哮证,可有效缓解患儿临床症状,提升治疗效果,且具有安全性.
Clinical Effect of Jiangqi Pingchuan Guben Decoction Combined with Acupoint Mas-sage in Treating Bronchial Asthma of Asthma Deficiency Syndrome and Its Influence on Immune Function of Pediatric Patients
Objective To explore the effect of Jiangqi Pingchuan Guben Decoction combined with acupoint mas-sage in the treatment of pediatric patients with bronchial asthma of asthma deficiency.Methods A total of 102 children with bronchial asthma of asthma deficiency syndrome admitted to Beijing Huairou Hospital of Traditional Chinese Medicine from November 2018 to June 2023 were selected and randomly divided into control and study groups,with 51 cases in each group.The control group was treated with conventional Western medicine,and the study group was treated with Jiangqi Pingchuan Guben Decoction combined with acupoint massage on the basis of the control group for four weeks.The clinical efficacy,incidence of adverse reactions,traditional Chinese medicine(TCM)syndrome score before and after treatment,lung functions[peak expiratory flow(PEF),forced expiratory volume in one second(FEV1),and forced vital capacity(FVC),and levels of immune functions interleukin-13(IL-13),interleukin-12(IL-12),interleukin-4(IL-4),and inter-feron-γ(IFN-γ)]in the two groups were observed and compared.Results After treatment,the total effective rate of the study group(92.16％,47/51)was higher than that of the control group(78.43％,40/51),and the difference was statistically significant(P＜0.05).After treatment,the scores for wheezing in the throat,cold limbs,weak cough and phlegm,sore waist and knees,fatigue,low voice,and short breath in the two groups are lower(P＜0.05).In addition,the TCM syndrome score of the study group was significantly lower than that of the control group(P＜0.05).After treatment,the PEF,FEV1,and FVC levels in the two groups were increased(P＜0.05),and the PEF,FEV1,and FVC levels in the study group were higher than those in the control group(P＜0.05).After treatment,the levels of IL-13 and IL-4 in the two groups were decreased,and the levels of IL-12 and IFN-γ were higher(P＜0.05).In addition,the levels of IL-13 and IL-4 in the study group were lower than those in the control group,and the levels of IL-12 and IFN-γ in the study group were higher than those in the control group(P＜0.05).During the treatment,there was no significant difference in the incidence of adverse reactions between the study group(5.88％,3/51)and the control group(3.92％,2/51)(P＞0.05).Conclu-sion Adopting Jiangqi Pingchuan Guben Decoction combined with acupoint massage to treat the bronchial asthma of asth-ma deficiency can effectively alleviate the clinical symptoms of pediatric patients and improve the treatment effect,with good safety.
Jiangqi Pingchuan Guben DecoctionAcupoint MassageBronchial AsthmaLung FunctionImmune Function
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