Efficacy of Zhenwu Decoction Combined with Modified Buxinqi Prescription in Treatment of Patients with Chronic Heart Failure of Heart and Kidney Yang Defi-ciency and Its Effects on Oxidative Stress and Vascular Endothelial Functions
Objective To investigate the clinical effects of Zhenwu Decoction combined with modified Buxinqi Prescription on patients with chronic heart failure(CHF)of heart and kidney Yang deficiency and its effects on oxidative stress and vascular endothelial functions.Methods A total of 110 patients with CHF admitted to Cardiovascular Depart-ment Ⅱ,Tangshan Hospital of Traditional Chinese Medicine from May 2020 to May 2022 were studied and divided into a control group and an observation group by random number table method,with 55 patients in each group.The control group was treated with conventional symptomatic treatment,and the observation group was treated with Zhenwu Decoction com-bined with modified Buxinqi Prescription on the basis of the control group.Patients in both groups were treated with three courses,with four weeks as a course.The clinical effects of the two groups were observed and compared,as well as the tra-ditional Chinese medicine(TCM)syndrome score before and after treatment,cardiac functions[left ventricular ejection frac-tion(LVEF),left ventricular end-diastolic diameter(LVEDD),and stroke volume(SV)],oxidative stress reactions(ser-um superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)],and vascular endo-thelial functions[serum endothelin-1(ET-1),vascular endothelial growth factor(VEGF),and nitric oxide(NO)].Re-sults After treatment,the total effective rate of the observation group was 92.73％(51/55),significantly higher than that of the control group of 77.36％(41/53),and the difference was statistically significant(P＜0.05).The TCM syndrome score of the two groups decreased(P＜0.05),and the TCM syndrome score of the observation group was lower than that of the control group(P＜0.05).After treatment,LVEF and SV levels in both groups were higher,and LVEDD levels were lower(P＜0.05).LVEF and SV levels in the observation group were significantly higher than those in the control group,and LVEDD levels were significantly lower than those in the control group(P＜0.05).After treatment,the levels of serum SOD and GSH-Px in both groups were higher,and the level of serum MDA was lower(P＜0.05).In addition,the levels of serum SOD and GSH-Px in the observation group were higher than those in the control group,and the level of serum MDA was lower than that in the control group(P＜0.05).After treatment,the serum ET-1 and NO levels in both groups were reduced,and the serum VEGF level was improved(P＜0.05).The serum ET-1 and NO levels in the observation group were lower than those in the control group,and the serum VEGF level was higher than that in the control group(P＜0.05).Conclusions Zhenwu Decoction combined with modified Buxinqi Prescription can be used to treat patients with CHF of heart and kidney Yang deficiency to strengthen the oxidative stress response,improve the vascular endothelial func-tion,promote the recovery of cardiac functions of patients,and enhance the overall treatment effect.
Chronic Heart FailureHeart and Kidney Yang DeficiencyZhenwu Decoction Combined With Modi-fied Buxinqi PrescriptionCardiac FunctionVascular Endothelial FunctionOxidative Stress Response
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