Biological Basis of Benign Prostatic Hyperplasia from the"Brain-Heart-Kidney-Semen Chamber"Axis
Benign prostatic hyperplasia(BPH)is characterized by difficulty in urination and its incidence has been increasing in recent years.According to traditional Chinese medicine(TCM),BPH is mainly related to kidney deficiency.On the basis of textual research and years of clinical experience,Professor Guo Jun puts forward the theory of"brain-heart-kidney-semen chamber"axis.He believes that the heart and brain in the upper energizer have the functions of storing spirit and regulating the physiological activities of the kidney and semen chamber.The kidneys and the semen chamber in the lower energizer govern the water flow and directly affect the metabolism of urine.The"brain-heart-kid-ney-semen chamber"axis connecting the upper and lower energizer can thus regulate the metabolism of urine as a whole.Disturbances in this axis can lead to BPH.The basic mechanisms of BPH include brain and heart dysfunctions,failure of spirit in governing,kidney deficiency,dysfunction of qi transformation,pathogen obstructing lower energizer,and dysfunc-tion of semen chamber.Accordingly,the clinical treatment of this disease should adopt the methods of regulating heart and benefiting brain,replenishing kidney and supplementing essence,and dredging semen chamber,which have yielded definite effects.This article systematically explains the molecular mechanisms of the three methods above in the treatment of BPH,laying a foundation for revealing the biological basis of treating BPH via the"brain-heart-kidney-semen chamber"ax-is.
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