Efficacy Study of Ankangxin Capsules-Assisted Small Incision Radical Gastrectomy for Gastric Cancer Patients
Objective To observe the clinical efficacy of Ankangxin capsules-assisted small incision radical gastrectomy for gastric cancer(GC).Methods From August 2021 to August 2022,70 patients with gastric cancer admit-ted to Tangshan People's Hospital in Hebei Province were selected as the study subjects.They were divided into a control and an observation group using the random number table method,with 35 patients in each group.The control group received small incision radical gastrectomy followed by nutritional intervention,while the observation group received Ankangxin cap-sules based on the control group.Both groups were treated for 4 weeks.Changes in traditional Chinese medicine(TCM)symptom scores[sluggish eating,dull pain in epigastrium,nausea and acid reflux,abdominal masses,loose stools],nutri-tional indicators[prealbumin(PA),hemoglobin(Hb),total protein(TP),albumin(Alb),transferrin(TRF)],gastrointesti-nal function indicators[bowel sound recovery time,first flatus time,dietary recovery time,first defecation time],tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen-724(CA-724),carbohydrate antigen-199(CA-199),malignant tumor growth factor(TSGF)],recurrence and metastasis indicators[matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor-A(VAGF-A)and(VAGF-C)],and immune function[T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+)]were observed and compared before and af-ter treatment between the two groups.Survival period,recurrence,and metastasis rate were recorded during follow-up.Re-sults After treatment,TCM main syndrome scores of sluggish eating,dull pain in epigastric,nausea and acid reflux,ab-dominal masses,and loose stools in both groups were significantly lower than before treatment,with a statistically significant difference(P＜0.05).The TCM syndrome scores of the observation group were significantly lower than those of the control group,with a statistically significant difference(P＜0.01).The observation group showed significantly better outcomes in bowel sound recovery time,first flatus time,dietary recovery time,and first defecation time than the control group,with a statistically significant difference(P＜0.01).After treatment,serum levels of PAB,Hb,TP,Alb,and TRF were significant-ly higher in both groups than before treatment,with a statistically significant difference(P＜0.05).The observation group showed significantly higher levels than the control group,with a statistically significant difference(P＜0.01).After treat-ment,tumor marker levels of TSGF,CEA,CA-724,and CA-199 decreased significantly in both groups,with a statistical-ly significant difference(P＜0.05).The observation group showed significantly lower levels than the control group,with a statistically significant difference(P＜0.01).After treatment,serum levels of MMP-2,MMP-9,VAGF-A,and VAGF-C were significantly lower in both groups than before treatment,with a statistically significant difference(P＜0.05).The observation group showed significantly lower levels than the control group,with a statistically significant difference(P＜0.01).There were no statistically significant differences in immune function indicators between the two groups before and after treatment(P＞0.05),whereas CD3+,CD4+,CD4+/CD8+levels increased and CD8+levels decreased significantly in the observation group compared to before treatment,with a statistically significant difference(P＜0.05).Furthermore,CD3+,CD4+,and CD4+/CD8+levels were significantly higher,and CD8+levels were significantly lower in the observa-tion group than in the control group(P＜0.01).The comparison of recurrence and metastasis rates between the two groups showed significant differences(x=5.535,5.878,P=0.019,0.015).Conclusion Ankangxin capsule-assisted small incision radical gastrectomy can effectively control the condition of gastric cancer patients,promote gastrointestinal function recovery,improve nutritional status and immune function,downregulate tumor markers and indicators of recurrence and me-tastasis,prolong survival,and reduce recurrence and metastasis.
Ankangxin CapsulesGastric CancerSmall Incision Radical GastrectomyTumor MarkersImmune Function
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维普
