Influence of Dampness-Reducing and Turbidity-Lowering Drink on Elderly Pa-tients with Spleen-Deficiency and Dampness-Blocking Gout
Objective To study the effect of dampness-reducing and turbidity-lowering drink on elderly pa-tients with spleen-deficiency and dampness-blocking gout.Methods Outpatient and inpatient medical records of 80 elderly patients with gout in Zhengzhou Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were selected as the study objects,and they were divided into a control group and treatment group according to the random num-ber table method,with 40 cases in each group.The control group was given febuxosita tablets,and the treatment group was given dampness-reducing and turbidity-lowering drink.The treatment course of both groups was four,eight,and 12 weeks.The clinical efficacy,total incidence rate of gout,safety,visual analogue scale(VAS)before and after treatment,TCM constitution changes,TCM syndrome scores,kidney functions[blood uric acid(BUA),serum creatinine concentration(SCR),and blood urea nitrogen(BUN)],and liver functions[aspartate aminotransferase(AST)and alanine aminotransferase(AST)]of the two groups were compared.Results VAS scores of the two groups after four,eight,and 12 weeks of treat-ment were lower,and VAS scores in the treatment group were significantly lower than those in the control group after 12 weeks of treatment,with a statistically significant difference(P＜0.05).The total incidence rate of gout in the treatment group was 18.92％(7/37)during treatment,significantly lower than that in the control group(40.00％,14/35)(P＜0.05).In the first two groups of patients,phlegm-dampness constitution＞damp-heat constitution＞Qi-deficiency constitution was the most.After treatment,the phlegm-dampness constitution and damp-heat constitution in the treatment group were significantly reduced,and the normal constitution was increased.After treatment,the control group had more Yang-deficiency constitution,blood stasis constitution,and normal constitution,and damp-heat constitution and Qi-de-ficiency constitution decreased.After four,eight,and 12 weeks of treatment,the TCM syndrome scores of the two groups were lower(P＜0.05).The TCM syndrome score of the treatment group was significantly lower than that of the control group(P＜0.05).It showed that TCM had obvious advantages in treating the clinical symptoms of chronic gout.After treat-ment,the total clinical effective rate of the treatment group was 94.59％(35/37),which was significantly higher than that of the control group 74.29％(26/35)(P＜0.05).After four weeks of treatment,there was no significant difference in the treatment group,but after 8 weeks of treatment,the BUA level decreased significantly(P＜0.05).After 12 weeks of treat-ment,the BUA level decreased slowly.The control group had an obvious uric acid lowering effect after four weeks of treat-ment(P＜0.05),and the decrease of BUA was not obvious after eight and 12 weeks of treatment,with the difference being not statistically significant(P＞0.05).During treatment,there were two cases of gastrointestinal discomfort in the treatment group and two cases in the control group,one case of abnormal urine routine in the control group,one case of abnormal ala-nine aminotransferase in the control group,two cases of abnormal alanine aminotransferase in the treatment group,one case of abnormal BUN in the treatment group,and two cases of abnormal BUN in the control group.Adverse reactions were rela-tively mild in patients,and no corresponding treatment was done.Conclusion The treatment of spleen deficiency and dampness-blocking gout with dampness-reducing and turbidity-lowering drink can obviously improve the constitution of TCM and the overall effect.The uric acid lowering effect of dampness-reducing and turbidity-lowering drink is more sta-ble than that of feburestat tablets,and it effectively reduces the attack of gout and the use of non-steroidal anti-inflam-matory drugs.The clinical effect is reliable and safe.
Dampness-Reducing and Turbidity-Lowering DrinkChronic GoutConstitution of Elderly PatientsBlood Uric Acid
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