Efficacy of Bushen Qiangdu Qinghua Decoction Combined with Etanercept in Trea-ting Ankylosing Spondylitis Patients with Kidney Deficiency and Damp-Heat Syn-drome
Objective To explore the therapeutic effect of Bushen Qiangdu Qinghua decoction combined with et-anercept in treating ankylosing spondylitis with kidney deficiency and damp-heat syndrome.Methods 86 patients with ankylosing spondylitis exhibiting kidney deficiency and damp-heat syndrome,who visited the Rheumatology Department of Linyi Hospital of Traditional Chinese Medicine from February 2021 to February 2023,were selected for the study.They were divided into a control group and a treatment group using the random number table method,with 43 patients in each group.The control group received etanercept,while the treatment group received Bushen Qiangdu Qinghua decoction in ad-dition to etanercept.The treatment lasted for 12 weeks.Observations were made on the traditional Chinese medicine(TCM)syndrome scores,inflammatory response indicators[erythrocyte sedimentation rate(ESR),serum interleukin-4(IL-4),tumor necrosis factor-alpha(TNF-α),C-reactive protein(CRP)],disease activity[Bath Ankylosing Spondylitis Func-tion Index(BASFI),Bath Ankylosing Spondylitis Disease Activity Index(BASDAI)],clinical efficacy,and adverse reac-tions before and after treatment.Results After treatment,the TCM syndrome scores in both groups significantly decreased compared to before treatment,with a statistically significant difference(P＜0.05).The TCM syndrome scores in the treat-ment group were significantly lower than those in the control group,with a statistically significant difference(P＜0.05).The levels of ESR,IL-4,TNF-α,and CRP in both groups significantly decreased after treatment compared to before treatment,with a statistically significant difference(P＜0.05).The levels of these inflammatory markers in the treatment group were significantly lower than those in the control group,with a statistically significant difference(P＜0.05).The BASFI and BASDAI scores in both groups significantly decreased after treatment compared to before treatment,with a sta-tistically significant difference(P＜0.05).The BASFI and BASDAI scores in the treatment group were significantly lower than those in the control group,with a statistically significant difference(P＜0.05).The total clinical effective rate in the treatment group after treatment was 95.35％(41/43),significantly higher than 79.07％(34/43)in the control group,with a statistically significant difference(P＜0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Bushen Qiangdu Qinghua decoction combined with etanercept is effective in reducing inflammatory responses and alleviating clinical symptoms in patients with ankylosing spondylitis exhibiting kidney deficiency and damp-heat syndrome.The combined treatment demonstrates sig-nificant clinical efficacy and does not cause notable adverse reactions.
Ankylosing SpondylitisBushen Qiangdu Qinghua DecoctionEtanerceptKidney Deficiency and Damp-Heat Syndrome
万方数据
维普
