Application of Traditional Chinese Medicine Syndrome Differentiation by Stages Treatment in Patients with Osteoporotic Vertebral Compression Fractures Post Per-cutaneous Vertebroplasty
Objective To investigate the effect of Traditional Chinese Medicine(TCM)syndrome differentiation by stages treatment on the fracture healing process and bone healing factors levels in patients with osteoporotic vertebral compression fracture(OVCF)post percutaneous vertebroplasty(PVP).Methods From January 2021 to June 2022,78 pa-tients with OVCF admitted to Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine were selected and divided into a control group(n=39)and a study group(n=39)based on the simple random table method.Both groups received PVP surgery,and the control group received routine postoperative intervention.The study group addi-tionally received TCM syndrome differentiation by stages treatment for one month.The fracture healing conditions(fracture healing effect,fracture healing time),pain degree[visual analogue scale(VAS)],lumbar function[oswestry disability in-dex(ODI)],and bone healing factor[fibroblast growth factor-2(FGF-2),transforming growth factor-β1(TGF-β1),alkaline phosphatase(ALP),insulin-like growth factor 1(IGF-1),bone morphogenetic protein-2(BMP-2)]levels,hemorheological status(plasma viscosity,erythrocyte aggregation index,whole blood low shear viscosity,whole blood high shear viscosity),and adverse reactions were observed and compared between the two groups.Results After treatment,the excellent rate of fracture healing in the study group was 71.79％(28/39),significantly higher than 46.15％(18/39)in the control group,and the healing time in the study group was significantly shorter than the control group,with a statistically significant difference(P＜0.05).On the first day and one month post-surgery,VAS and ODI scores in both groups were significantly lower than preoperative scores,with a statistically significant difference(P＜0.05);the study group showed significantly lower VAS and ODI scores than the control group,with a statistically significant difference(P＜0.05).At one week and one month post-surgery,serum levels of FGF-2,TGF-β1,ALP,IGF-1,and BMP-2 in both groups were significantly higher than preoperative levels,with a statistically significant difference(P＜0.05);the study group showed significantly higher levels than the control group,with a statistically significant difference(P＜0.05).Additionally,at one week and one month post-surgery,plasma viscosity,erythrocyte aggregation index,whole blood low shear viscosity,and whole blood high shear viscosity in both groups were significantly lower than preoperative levels,with a statistically signifi-cant difference(P＜0.05);the study group showed significantly lower levels than the control group,with a statistically sig-nificant difference(P＜0.05).During the treatment period,the incidence of adverse reactions in the study group was 5.13％(2/39),significantly lower than 23.08％(9/39)in the control group,with a statistically significant difference(P＜0.05).Conclusion Implementing TCM syndrome differentiation by stages treatment for OVCF patients post-PVP sur-gery effectively regulates hemorheological status,upregulates the expression of bone healing factor,shortens the fracture healing process,improves fracture healing effect,alleviates pain,and enhances lumbar function,with higher safety.
万方数据
维普
