Bushen Qiangyao Decoction Combined with Pestle Needle Therapy Regulates Lumbar Function,Immune Function,and Oxidative Stress in Patients with Ankylosing Spondy-litis
Objective To observe the effects of Bushen Qiangyao Decoction combined with pestle needle therapy on lumbar function,immune function,and oxidative stress in the patients with ankylosing spondylitis(AS)and syndrome of kidney deficiency and dampness-heat.Methods Ninety-two patients with AS treated in the First Affiliated Hospital of Xinjiang Medical University from April 2021 to August 2023 were selected and assigned into the control and observation groups(n=46)by complete randomization.The control group was treated with conventional Western medicine,while the observation group was treated with Bushen Qiangyao Decoction combined with pestle needle therapy on the basis of the therapy in the control group.The treatment lasted for 8 weeks,and the therapeutic effect was compared between the two groups.The clinical indicators(finger-ground distance and pillow-wall distance),lumbar function,immunoglobulins(IgG,IgM),oxidative stress factors[malondialdehyde(MDA),superoxide dismutase(SOD),and total antioxidant capacity(TAOC)],erythrocyte sedimentation rate(ESR),interleukin-17(IL-17),interleukin-23(IL-23),traditional Chi-nese medicine(TCM)symptom score,ankylosing spondylitis disease activity score(ASDAS)score,and bath ankylosing spondylitis functional index(BASFI)were determined before and after treatment.Results After treatment,the morning stiffness time,finger-ground distance,and pillow-wall distance shortened,while the lumbar spine mobility and thoracic mobility increased(P＜0.05).Moreover,the observation group had shorter morning stiffness time,finger-ground dis-tance,and pillow-wall distance and higher lumbar spine mobility and thoracic mobility than the control group(P＜0.05).After treatment,the levels of IgG and IgM in both groups elevated(P＜0.05),and the observation group had higher IgG and IgM levels than the control group(P＜0.05).The treatment in both groups lowered the MDA,ESR,IL-17,and IL-23 levels and elevated the TAOC and SOD levels(P＜0.05),and the changes in the observation group were higher than those in the control group(P＜0.05).After treatment,the scores of TCM symptoms,ASDAS,and BASFI declined in both groups(P＜0.05),and the observation group had lower scores than the control group(P＜0.05).The total response rate in the observation group was 91.30％(42/46),which was higher than that(76.09％,35/46)in the control group(P＜0.05).Conclusion Bushen Qiangyao Decoction combined with pestle needle therapy can improve the lumbar function,enhance the immune function,and inhibit oxidative stress in AS patients with the syndrome of kidney deficiency and damp-ness-heat.
Bushen Qiangyao DecoctionPestle NeedleAnkylosing SpondylitisSyndrome of Kidney Deficiency and Dampness-HeatLumbar FunctionImmune FunctionOxidative Stress
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